Mutations in BRCA1/BARD1 RING-domain heterodimer
From Proteopedia
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*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>. | *<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>. | ||
To begin with scenes, please click in the following order: "Mutation ...", after that on "Wild type", "Mutation" and so on. | To begin with scenes, please click in the following order: "Mutation ...", after that on "Wild type", "Mutation" and so on. | ||
| - | *'''Mutation L22S''' | + | *'''Mutation L22S:''' <scene name='75/751104/L22s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/L22s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/L22s/2'>Click here to see animation of this scene</scene>. Putative new hydrogen bonds were added. |
| - | *<scene name='75/751104/T37k/ | + | *'''Mutation T37K:''' <scene name='75/751104/T37k/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/T37k/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/T37k/2'>Click here to see animation of this scene</scene>. |
| - | *<scene name='75/751104/Cv/15'>Mutation C39R</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/16'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/Cv/15'>Mutation C39R</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/16'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond. |
| - | *<scene name='75/751104/H41r/3'>Mutation H41R</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/H41r/4'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/H41r/3'>Mutation H41R</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/H41r/4'>Click here to see animation of this scene</scene>. This mutation causes missing of N-Zn bond. |
| - | *<scene name='75/751104/C44s/1'>Mutation C44S</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/C44s/1'>Mutation C44S</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond. |
| - | *<scene name='75/751104/C44y/1'>Mutation C44Y</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44y/2'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/C44y/1'>Mutation C44Y</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44y/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond. |
| - | *<scene name='75/751104/C61g/1'>Mutation C61G</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C61g/2'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/C61g/1'>Mutation C61G</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C61g/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond. |
==Benign mutations== | ==Benign mutations== | ||
| - | *<scene name='75/751104/Cv/24'>Mutation K45Q</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/25'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/Cv/24'>Mutation K45Q</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/25'>Click here to see animation of this scene</scene>. |
| - | *<scene name='75/751104/Cv/11'>Mutation D67Y</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/10'>Click here to see animation of this scene</scene> | + | *<scene name='75/751104/Cv/11'>Mutation D67Y</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/Cv/10'>Click here to see animation of this scene</scene>. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
Revision as of 08:32, 5 February 2017
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References
- ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833
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