Mutations in BRCA1/BARD1 RING-domain heterodimer

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*'''Mutation C44S:''' <scene name='75/751104/C44s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond.
*'''Mutation C44S:''' <scene name='75/751104/C44s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44s/2'>Click here to see animation of this scene</scene>. This mutation causes missing of S-Zn bond.
*'''Mutation C44Y:''' <scene name='75/751104/C44y/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44y/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44y/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.
*'''Mutation C44Y:''' <scene name='75/751104/C44y/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C44y/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C44y/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.
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*<scene name='75/751104/C61g/1'>Mutation C61G</scene>. <jmol><jmolButton><script>frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C61g/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.
+
*'''Mutation C61G:''' <scene name='75/751104/C61g/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/C61g/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/C61g/2'>Click here to see animation of this scene</scene> This mutation causes missing of S-Zn bond.
==Benign mutations==
==Benign mutations==

Revision as of 08:50, 5 February 2017

PDB ID 1jm71.pdb

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References

  1. ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman

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