Mutations in BRCA1/BARD1 RING-domain heterodimer
From Proteopedia
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*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>. | *<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>. | ||
To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on. | To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on. | ||
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| + | *<scene name='75/751104/L22s/3'>Mutation L22S:</scene><jmol><jmolButton><script>animation off; frame 1</script><text>Wild type</text></jmolButton></jmol> and the <jmol><jmolButton><script>animation off; frame 2</script><text>Mutation</text></jmolButton></jmol>. <jmol><jmolButton><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolButton></jmol>. <jmol><jmolButton><script>animation on; animation mode palindrome; frame play</script><text>Click here to see animation of this scene</text></jmolButton></jmol>. Putative new hydrogen bonds were added. | ||
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*'''Mutation L22S:''' <scene name='75/751104/L22s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/L22s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/L22s/2'>Click here to see animation of this scene</scene>. Putative new hydrogen bonds were added. | *'''Mutation L22S:''' <scene name='75/751104/L22s/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/L22s/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/L22s/2'>Click here to see animation of this scene</scene>. Putative new hydrogen bonds were added. | ||
*'''Mutation T37K:''' <scene name='75/751104/T37k/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/T37k/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/T37k/2'>Click here to see animation of this scene</scene>. | *'''Mutation T37K:''' <scene name='75/751104/T37k/3'>Wild type</scene> and the <jmol><jmolButton><script>frame next</script><text>Mutation</text></jmolButton></jmol>. <scene name='75/751104/T37k/1'>Mutated and wildtype residues together</scene>. <scene name='75/751104/T37k/2'>Click here to see animation of this scene</scene>. | ||
Revision as of 04:49, 9 February 2017
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References
- ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833
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Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
