1sd5
From Proteopedia
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|GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | |GENE= rv1626 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 Mycobacterium tuberculosis H37Rv]) | ||
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03861 ANTAR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00156 REC], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3707 AmiR]</span> | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam03861 ANTAR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00156 REC], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3707 AmiR]</span> | ||
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sd5 OCA], [http://www.ebi.ac.uk/pdbsum/1sd5 PDBsum | + | |RELATEDENTRY=[[1s8n|1S8N]] |
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sd5 OCA], [http://www.ebi.ac.uk/pdbsum/1sd5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sd5 RCSB]</span> | ||
}} | }} | ||
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[[Category: two components system]] | [[Category: two components system]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:40:28 2008'' |
Revision as of 20:40, 30 March 2008
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| , resolution 1.68Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | rv1626 (Mycobacterium tuberculosis H37Rv) | ||||||
| Domains: | ANTAR, REC, AmiR | ||||||
| Related: | 1S8N
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Rv1626
Overview
We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems. The C-terminal domain has high structural homology to a recently discovered RNA binding domain involved in transcriptional antitermination. The molecule in solution was found to be monomeric as it is in the crystal, but in solution it undergoes a conformational change that is triggered by changes in ionic strength. This is the first structure that links the phosphorylation cascade of the two-component systems with the antitermination event in the transcriptional machinery. Rv1626 belongs to a family of proteins, which we propose calling phosphorylation-dependent transcriptional antitermination regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
About this Structure
1SD5 is a Single protein structure of sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:15341725
Page seeded by OCA on Sun Mar 30 23:40:28 2008
Categories: Mycobacterium tuberculosis h37rv | Single protein | Feng, V. | Morth, J P. | Perry, L J. | Svergun, D I. | TBSGC, TB Structural Genomics Consortium. | Tucker, P A. | Antiterminator | Protein structure initiative | Psi | Rv1626 | Structural genomic | Tb structural genomics consortium | Tbsgc | Transcriptional | Two components system
