Mutations in BRCA1/BARD1 RING-domain heterodimer
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*<scene name='75/751104/L22s/5'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. <jmol><jmolButton><script>if (_animating); anim pause;set echo bottom left; color echo white; font echo 20 sansserif;echo Animation Paused; else; anim resume; set echo off;endif;</script> <text>Toggle Animation</text></jmolButton></jmol> N.b. putative new hydrogen bonds were added. | *<scene name='75/751104/L22s/5'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. <jmol><jmolButton><script>if (_animating); anim pause;set echo bottom left; color echo white; font echo 20 sansserif;echo Animation Paused; else; anim resume; set echo off;endif;</script> <text>Toggle Animation</text></jmolButton></jmol> N.b. putative new hydrogen bonds were added. | ||
Revision as of 10:32, 14 February 2017
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References
- ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833
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Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
