Mutations in BRCA1/BARD1 RING-domain heterodimer

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 8: Line 8:
*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>.
*<scene name='75/751104/Cv/21'>Pathogenic mutations in RING domain</scene>.
-
To begin with scenes, please click the green link with the name of the mutation.
 
-
*<scene name='75/751104/L22s/3'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. Putative new hydrogen bonds were added. <scene name='75/751104/L22s/6'>TextToBeDisplayed</scene>
 
-
'''MY EXAMPLE:'''
+
*<scene name='75/751104/L22s/3'>Mutation L22S: </scene>
-
<scene name='75/751104/L22s/6'>Should be with green halos</scene>.
+
<jmol>
-
 
+
<jmolLink>
-
*<scene name='75/751104/L22s/5'>Mutation L22S: </scene> <jmol><jmolLink><script>animation off; frame 2</script><text>Mutation</text></jmolLink></jmol> and the <jmol><jmolLink><script>animation off; frame 1</script><text>Wild type</text></jmolLink></jmol>. <jmol><jmolLink><script>animation off; frame all</script><text>Mutated and wildtype residues together</text></jmolLink></jmol>. Click here to see an <jmol><jmolLink><script>animation on; animation mode loop; frame play</script><text>animation</text></jmolLink></jmol> of both states. <jmol><jmolButton><script>if (_animating); anim pause;set echo bottom left; color echo white; font echo 20 sansserif;echo Animation Paused; else; anim resume; set echo off;endif;</script> <text>Toggle Animation</text></jmolButton></jmol> N.b. putative new hydrogen bonds were added.
+
<script>
 +
animation on; animation mode loop; frame 1 1 play; animation off; frame 1;
 +
</script>
 +
<text>Wild type conformation,</text>
 +
</jmolLink>
 +
</jmol>
 +
and this renders the
 +
<jmol>
 +
<jmolLink>
 +
<script>
 +
animation on; animation mode loop; frame 2 2 play; animation off; frame 2;
 +
</script>
 +
<text>Mutation
 +
</text>
 +
</jmolLink>
 +
</jmol>
 +
Click here to see the
 +
<jmol>
 +
<jmolLink>
 +
<script>
 +
animation off; frame all
 +
</script>
 +
<text>Mutated and wildtype residues
 +
</text>
 +
</jmolLink>
 +
</jmol> together. Click here to
 +
<jmol>
 +
<jmolLink>
 +
<script>
 +
animation on; animation mode loop; frame play
 +
</script>
 +
<text>see animation
 +
</text>
 +
</jmolLink>
 +
</jmol> of both states. Putative new hydrogen bonds were added.
To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on.
To begin with scenes, please click in the following order: on "Wild type", after that "Mutation" and so on.

Revision as of 11:17, 15 February 2017

PDB ID 1jm71.pdb

Drag the structure with the mouse to rotate

References

  1. ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Mutations_in_BRCA1/BARD1_RING-domain_heterodimer"
Personal tools