Mutations in BRCA1/BARD1 RING-domain heterodimer
From Proteopedia
(Difference between revisions)
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animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [LEU]22;color selectionHalos green;selectionHalos on; | animation on; animation mode loop; frame 1 1 play; animation off; frame 1; select [LEU]22;color selectionHalos green;selectionHalos on; | ||
</script> | </script> | ||
| - | <text>Wild type | + | <text>Wild type </text> |
</jmolLink> | </jmolLink> | ||
</jmol> | </jmol> | ||
| - | and | + | conformation and |
<jmol> | <jmol> | ||
<jmolLink> | <jmolLink> | ||
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animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [SER]22;color selectionHalos red;selectionHalos on; | animation on; animation mode loop; frame 2 2 play; animation off; frame 2; select [SER]22;color selectionHalos red;selectionHalos on; | ||
</script> | </script> | ||
| - | <text> | + | <text>mutation. |
</text> | </text> | ||
</jmolLink> | </jmolLink> | ||
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animation off; frame all; select [LEU]22;color selectionHalos green;selectionHalos on; select [SER]22;color selectionHalos red;selectionHalos on; | animation off; frame all; select [LEU]22;color selectionHalos green;selectionHalos on; select [SER]22;color selectionHalos red;selectionHalos on; | ||
</script> | </script> | ||
| - | <text> | + | <text>mutated and wildtype residues |
</text> | </text> | ||
</jmolLink> | </jmolLink> | ||
| - | </jmol> together | + | </jmol> together, and an |
<jmol> | <jmol> | ||
<jmolLink> | <jmolLink> | ||
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animation on; animation mode loop; frame play; select [LEU]22;color selectionHalos green;selectionHalos on; select [SER]22;color selectionHalos red;selectionHalos on; | animation on; animation mode loop; frame play; select [LEU]22;color selectionHalos green;selectionHalos on; select [SER]22;color selectionHalos red;selectionHalos on; | ||
</script> | </script> | ||
| - | <text> | + | <text>animation |
</text> | </text> | ||
</jmolLink> | </jmolLink> | ||
| - | </jmol> | + | </jmol> between the two states. Putative new hydrogen bonds were added. |
Revision as of 17:23, 15 February 2017
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References
- ↑ Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 doi:10.1038/nsb1001-833
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Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman
