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4mnb
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnb OCA], [http://pdbe.org/4mnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnb RCSB], [http://www.ebi.ac.uk/pdbsum/4mnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnb OCA], [http://pdbe.org/4mnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnb RCSB], [http://www.ebi.ac.uk/pdbsum/4mnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. | ||
| + | |||
| + | Intercalative DNA binding of the marine anticancer drug variolin B.,Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169<ref>PMID:28051169</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4mnb" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:18, 9 March 2017
Crystal Structure of a complex between the marine anticancer drug Variolin B and DNA
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Categories: Albericio, F | Alvarez, M | Arribas-Bosacoma, R | Aymami, J | Canals, A | Coll, M | Dna | Dna duplex | Drug binding | Intercalation | Nucleus
