5lg4

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m (Protected "5lg4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5lg4 is ON HOLD
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==Crystal structure of the Sec3/Sso2 complex at 2.9 angstrom resolution==
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<StructureSection load='5lg4' size='340' side='right' caption='[[5lg4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5lg4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LG4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg4 OCA], [http://pdbe.org/5lg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5lg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SSO2_YEAST SSO2_YEAST]] Required for vesicle fusion with the plasma membrane. [[http://www.uniprot.org/uniprot/SEC3_YEAST SEC3_YEAST]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The soluble N-ethylmaleimide-sensitive factor-attachment protein receptors (SNAREs) constitute the core machinery for membrane fusion during eukaryotic cell vesicular trafficking. However, how the assembly of the SNARE complex is initiated is unknown. Here we report that Sec3, a component of the exocyst complex that mediates vesicle tethering during exocytosis, directly interacts with the t-SNARE protein Sso2. This interaction promotes the formation of an Sso2-Sec9 'binary' t-SNARE complex, the early rate-limiting step in SNARE complex assembly, and stimulates membrane fusion. The crystal structure of the Sec3-Sso2 complex suggests that Sec3 binding induces conformational changes of Sso2 that are crucial for the relief of its auto-inhibition. Interestingly, specific disruption of the Sec3-Sso2 interaction in cells blocks exocytosis without affecting the function of Sec3 in vesicle tethering. Our study reveals an activation mechanism for SNARE complex assembly, and uncovers a role of the exocyst in promoting membrane fusion in addition to vesicle tethering.
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Authors:
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Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.,Yue P, Zhang Y, Mei K, Wang S, Lesigang J, Zhu Y, Dong G, Guo W Nat Commun. 2017 Jan 23;8:14236. doi: 10.1038/ncomms14236. PMID:28112172<ref>PMID:28112172</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5lg4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dong, G]]
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[[Category: Zhang, Y B]]
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[[Category: Coiled-coil]]
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[[Category: Exocyst]]
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[[Category: Sec3]]
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[[Category: Sso2]]
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[[Category: Structural protein]]

Revision as of 09:26, 10 March 2017

Crystal structure of the Sec3/Sso2 complex at 2.9 angstrom resolution

5lg4, resolution 2.90Å

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