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5ail
From Proteopedia
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==Human PARP9 2nd macrodomain== | ==Human PARP9 2nd macrodomain== | ||
<StructureSection load='5ail' size='340' side='right' caption='[[5ail]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='5ail' size='340' side='right' caption='[[5ail]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aik|5aik]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aik|5aik]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ail FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ail OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ail RCSB], [http://www.ebi.ac.uk/pdbsum/5ail PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ail FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ail OCA], [http://pdbe.org/5ail PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ail RCSB], [http://www.ebi.ac.uk/pdbsum/5ail PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ail ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN]] In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.<ref>PMID:16809771</ref> <ref>PMID:23230272</ref> | [[http://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN]] In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.<ref>PMID:16809771</ref> <ref>PMID:23230272</ref> | ||
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| + | ==See Also== | ||
| + | *[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 09:57, 10 March 2017
Human PARP9 2nd macrodomain
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Categories: Arrowsmith, C | Bountra, C | Delft, F von | Edwards, A M | Elkins, J M | Knapp, S | Shrestha, L | Sieg, C | Sorrell, F | Talon, R | Williams, E | Transcription
