Baculoviral IAP repeat-containing protein
From Proteopedia
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*'''Baculoviral IAP repeat-containing protein 2''' (cIAP1) and '''Baculoviral IAP repeat-containing protein 3''' (cIAP2) inhibit apoptosis by interfering with the activation of caspase and by binding to TNFR-associated factors TRAF1 and TRAF2. cIAP1 is a multi-functional protein which acts as an E3 ubiquitin-protein ligase and plays a role in the modulation of the cell cycle. cIAP1 is involved in controlling b-cell survival under ER stress caused by lipotoxicity. Both cIAP1 and cIAP2 regulate NF-kB activation. cIAP2 inhibits apoptosis caused by serum deprivation but not by inducers of free radicals. <br /> | *'''Baculoviral IAP repeat-containing protein 2''' (cIAP1) and '''Baculoviral IAP repeat-containing protein 3''' (cIAP2) inhibit apoptosis by interfering with the activation of caspase and by binding to TNFR-associated factors TRAF1 and TRAF2. cIAP1 is a multi-functional protein which acts as an E3 ubiquitin-protein ligase and plays a role in the modulation of the cell cycle. cIAP1 is involved in controlling b-cell survival under ER stress caused by lipotoxicity. Both cIAP1 and cIAP2 regulate NF-kB activation. cIAP2 inhibits apoptosis caused by serum deprivation but not by inducers of free radicals. <br /> | ||
*For '''Baculoviral IAP repeat-containing protein 4''' see XIAP in [[Ubiquitin protein ligase]].<br /> | *For '''Baculoviral IAP repeat-containing protein 4''' see XIAP in [[Ubiquitin protein ligase]].<br /> | ||
| + | *For '''Baculoviral IAP repeat-containing protein 5''' see [[Survivin]].<br /> | ||
*'''Baculoviral IAP repeat-containing protein 6''' (BIRC6) inhibits caspase-3,7,9. Has a role in the final stages of cytokinesis, vescilcle targeting to the site of abscission and ubiquitin conjugation.<br /> | *'''Baculoviral IAP repeat-containing protein 6''' (BIRC6) inhibits caspase-3,7,9. Has a role in the final stages of cytokinesis, vescilcle targeting to the site of abscission and ubiquitin conjugation.<br /> | ||
*'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br /> | *'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br /> | ||
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**[[3m0d]] – hcIAP2 BIR1 domain + TNF-associated factor 1 + TNF-associated factor 2 <br /> | **[[3m0d]] – hcIAP2 BIR1 domain + TNF-associated factor 1 + TNF-associated factor 2 <br /> | ||
**[[3m0a]] – hcIAP2 BIR1 domain + TNF-associated factor 2 <br /> | **[[3m0a]] – hcIAP2 BIR1 domain + TNF-associated factor 2 <br /> | ||
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| + | *Baculoviral IAP repeat-containing protein 4 see [[E3 ubiquitin-protein ligase]] | ||
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| + | *Baculoviral IAP repeat-containing protein 5 see [[Survivin]] | ||
*Baculoviral IAP repeat-containing protein 6 (BIRC6) | *Baculoviral IAP repeat-containing protein 6 (BIRC6) | ||
Revision as of 07:45, 14 March 2017
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3D Structures of Baculoviral IAP repeat-containing protein
Updated on 14-March-2017
References
- ↑ Deveraux QL, Reed JC. IAP family proteins--suppressors of apoptosis. Genes Dev. 1999 Feb 1;13(3):239-52. PMID:9990849
- ↑ Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25;280(12):11147-51. Epub 2005 Jan 18. PMID:15657060 doi:10.1074/jbc.M413787200
