Vasodilator-stimulated phosphoprotein
From Proteopedia
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| - | <StructureSection load='2pbd' size='400' side='right' caption='Human VASP (dark olive) complex with α-actin (cyan), profilin-1 (green), ATP and Ca+2 ion (green), [[2pbd]]' scene='50/508423/Cv/ | + | <StructureSection load='2pbd' size='400' side='right' caption='Human VASP (dark olive) complex with α-actin (cyan), profilin-1 (green), ATP and Ca+2 ion (green), [[2pbd]]' scene='50/508423/Cv/3' pspeed='8'> |
== Function == | == Function == | ||
'''Vasodilator-stimulated phosphoprotein''' (VASP) belongs to the Ena-VASP family. It binds proteins with E/DFPPPPXD/E motif and targets them to focal adhesion cell membranes. VASP is an actin- and profilin-binding protein<ref>PMID:16197368</ref>. VASP is associated with filament formation and promotes elongation. | '''Vasodilator-stimulated phosphoprotein''' (VASP) belongs to the Ena-VASP family. It binds proteins with E/DFPPPPXD/E motif and targets them to focal adhesion cell membranes. VASP is an actin- and profilin-binding protein<ref>PMID:16197368</ref>. VASP is associated with filament formation and promotes elongation. | ||
Revision as of 08:04, 27 March 2017
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3D structure of vasodilator-stimulated phosphoprotein
Updated on 27-March-2017
1egx – hVASP EVH1 domain – human – NMR
1usd, 1use - hVASP tetramerization domain
2pav, 2pbd, 3chw – hVASP + actin + profilin-1
References
- ↑ Wentworth JK, Pula G, Poole AW. Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochem J. 2006 Jan 15;393(Pt 2):555-64. PMID:16197368 doi:http://dx.doi.org/BJ20050796
- ↑ Lee SY, Gertler FB, Goldberg MB. Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery. Microbiology. 2015 Nov;161(11):2149-60. doi: 10.1099/mic.0.000173. Epub 2015 Sep , 9. PMID:26358985 doi:http://dx.doi.org/10.1099/mic.0.000173
- ↑ Ferron F, Rebowski G, Lee SH, Dominguez R. Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J. 2007 Oct 31;26(21):4597-606. Epub 2007 Oct 4. PMID:17914456
