This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5m7r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5m7r is ON HOLD until Paper Publication
+
==Structure of human O-GlcNAc hydrolase==
-
 
+
<StructureSection load='5m7r' size='340' side='right' caption='[[5m7r]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5m7r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M7R FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7r OCA], [http://pdbe.org/5m7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7r RCSB], [http://www.ebi.ac.uk/pdbsum/5m7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7r ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Britton, R]]
 +
[[Category: Chan, S]]
 +
[[Category: Davies, G J]]
 +
[[Category: Hemsworth, G R]]
 +
[[Category: King, D]]
 +
[[Category: Offen, W A]]
 +
[[Category: Roth, C]]
 +
[[Category: Varghese, V]]
 +
[[Category: Vocadlo, D J]]
 +
[[Category: Willems, L I]]
 +
[[Category: Human glacoside hydrolase glcnac]]
 +
[[Category: Hydrolase]]

Revision as of 13:46, 29 March 2017

Structure of human O-GlcNAc hydrolase

5m7r, resolution 2.35Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m7r"
Personal tools