1tx7
From Proteopedia
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|PDB= 1tx7 |SIZE=350|CAPTION= <scene name='initialview01'>1tx7</scene>, resolution 1.75Å | |PDB= 1tx7 |SIZE=350|CAPTION= <scene name='initialview01'>1tx7</scene>, resolution 1.75Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=4CM:(4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC+ACID'>4CM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tx7 OCA], [http://www.ebi.ac.uk/pdbsum/1tx7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tx7 RCSB]</span> | ||
}} | }} | ||
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[[Category: Marankan, F.]] | [[Category: Marankan, F.]] | ||
[[Category: Mesecar, A.]] | [[Category: Mesecar, A.]] | ||
| - | [[Category: 4CM]] | ||
| - | [[Category: CA]] | ||
[[Category: bovine]] | [[Category: bovine]] | ||
[[Category: p-amidinophenylmethylphosphinic acid (ampa)]] | [[Category: p-amidinophenylmethylphosphinic acid (ampa)]] | ||
[[Category: trypsin]] | [[Category: trypsin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:02:23 2008'' |
Revision as of 21:02, 30 March 2008
| |||||||
| , resolution 1.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Trypsin, with EC number 3.4.21.4 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)
Overview
p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole.
About this Structure
1TX7 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:11738605
Page seeded by OCA on Mon Mar 31 00:02:23 2008
