This is a default text for your page Elizabeth A. Dunlap/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

Disease

Lymphoma is a blood cancer that consists of lymphocytes (specific kinds of white blood cells) growing and multiplying without restriction. These cancerous cells are then dispatched to the lymph nodes, blood, bone marrow and spleen, among other organs. The accumulation of these cells forms a tumor. One type of lymphocyte that can develop into a cancerous cell is T-lymphocytes (T-cells). An extremely prevalent type of T-cell lymphoma is cutaneous T-cell lymphoma (CTCL) which involves T-cell lymphomas that inflict damage on the skin. CTCL is a non-Hodgkin type of lymphoma that can also have negative impacts on the lymph nodes, blood, spleen, and other organs. Patients often have dry skin accompanied with a rash and itching, as well as swollen lymph nodes. Patches, plaques, or tumors on the skin are characteristic of mycosis fungoides which is a mild type of CTCL. The majority of the time these symptoms are the only ones present, however, ten percent of patients that have later stages of the disease can develop severe complications. Sezary syndrome is a progressed form of mycosis fungoides that is identified by lymphoma cells appearing in the blood. This syndrome is systemic and chronic and has much more invasive symptoms such as red, itchy rashes covering over eighty percent of a patient’s body. Patients with this syndrome may also have patches and tumors on the skin, as well as alterations in hair, eyelids, nails, and enlargement of their lymph nodes. Zolinza is used to treat cutaneous manifestations that arise with CTCL, and this treatment is only recommended for patients that have undergone at least two systematic therapies with no improvement in their condition.

Relevance

Structural highlights

Zolinza contains vorinostat which is a histone deacetylase (HDAC) inhibitor. It’s IUPAC name is N'-hydroxy-N-phenyloctanediamide. Vorinostat has a molecular formula of C14H20N2O3 and a molecular weight of 263.32 g/mol. It has a melting point ranging from 159 to 160.5 degrees Celsius. This HDAC inhibitor is freely soluble in dimethylsulfide, somewhat soluble in water but more so than in ethanol, isopropanol, and acetone, and insoluble in methylene chloride. It’s pH value in water solution is 6.6 with a pKa value of 9.2.

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.