Sandbox GGC2

Glucokinase is also known as human hexokinase IV. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.

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Structure

Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a and a . At the of glucoskinase, glucose molecule form hydrogen bonds with Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI)will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site.

Function

Disease

Relevance

Structural highlights

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