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Trichodiene synthase
From Proteopedia
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| - | <StructureSection load='2q9y' size='450' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene=''> | + | <StructureSection load='2q9y' size='450' side='right' caption='Trichodiene synthase complex with diphosphate, competitive inhibitor and Mg+2 ion (green) [[2q9y]]' scene='54/542259/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
'''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif<ref>PMID:7875326</ref>. | '''Trichodiene synthase''' (TCS) catalyzes the conversion of trans,trans-farnesyl diphosphate to trichodiene and diphosphate (PP). TCS belongs to the family of sesquiterpene syntases which cyclize the acyclic farnesyl diphosphate to a sesquiterpene. TCS contains metal ion-binding motif<ref>PMID:7875326</ref>. | ||
Revision as of 10:07, 18 April 2017
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3D Structures of trichodiene synthase
Updated on 18-April-2017
1jfa – FsTCS – Fusarium sporotrichioides
1kiy, 1yj4, 2ps6 – FsTCS (mutant)
2aek, 2ps4, 2ps7 – FsTCS (mutant) + Mg
1jfg, 2q9z – FsTCS + PP + Mg
1kiz, 1yyq, 2ps5, 2ps8 – FsTCS (mutant) + PP + Mg
1yyr, 1yys, 1yyt, 1yyu, 2ael, 2aet – FsTCS (mutant) + PP + Mg + azabisabolene
2q9y – FsTCS + PP + Mg + benzyl triethyl ammonium
References
- ↑ Bardot O, Clemencet MC, Passilly P, Latruffe N. The analysis of modified peroxisome proliferator responsive elements of the peroxisomal bifunctional enzyme in transfected HepG2 cells reveals two regulatory motifs. FEBS Lett. 1995 Feb 27;360(2):183-6. PMID:7875326
- ↑ Vedula LS, Zhao Y, Coates RM, Koyama T, Cane DE, Christianson DW. Exploring biosynthetic diversity with trichodiene synthase. Arch Biochem Biophys. 2007 Oct 15;466(2):260-6. Epub 2007 Jun 28. PMID:17678871 doi:10.1016/j.abb.2007.06.016
