This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1url
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1url |SIZE=350|CAPTION= <scene name='initialview01'>1url</scene>, resolution 2.40Å | |PDB= 1url |SIZE=350|CAPTION= <scene name='initialview01'>1url</scene>, resolution 2.40Å | ||
|SITE= <scene name='pdbsite=AC1:Sia+Binding+Site+For+Chain+B'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Sia+Binding+Site+For+Chain+B'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=SIA:O-SIALIC ACID'>SIA</scene> | + | |LIGAND= <scene name='pdbligand=HIA:L-HISTIDINE+AMIDE'>HIA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1url FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1url OCA], [http://www.ebi.ac.uk/pdbsum/1url PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1url RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Hilaire, P M.S.]] | [[Category: Hilaire, P M.S.]] | ||
[[Category: Meldal, M.]] | [[Category: Meldal, M.]] | ||
| - | [[Category: SIA]] | ||
[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
[[Category: immunoglobulin domain]] | [[Category: immunoglobulin domain]] | ||
| Line 35: | Line 37: | ||
[[Category: sialoadhesin]] | [[Category: sialoadhesin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:12 2008'' |
Revision as of 21:14, 30 March 2008
| |||||||
| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH GLYCOPEPTIDE
Overview
Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages. It is a model system for Siglec receptor-mediated cell surface interactions through binding of sialylated glycoconjugates. The N-terminal sialoadhesin domain can mediate sialic acid-binding on its own. The structure of this domain has been determined in complex with a sialic acid-containing heptapeptide, (Ala-Gly-His-Thr(Neu5Ac)-Trp-Gly-His). The affinity of sialoadhesin for this ligand is four times higher than the affinity for the natural linkage 2,3'-sialyllactose. The structure of the glycopeptide complex suggests strategies for ligand optimization and provides possible explanations for the observed differences in specificities among the Siglecs.
About this Structure
1URL is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Complex of sialoadhesin with a glycopeptide ligand., Bukrinsky JT, St Hilaire PM, Meldal M, Crocker PR, Henriksen A, Biochim Biophys Acta. 2004 Nov 1;1702(2):173-9. PMID:15488769
Page seeded by OCA on Mon Mar 31 00:14:12 2008
