Elongation factor

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Line 49: Line 49:
**[[4v68]] – TtEF + antibiotic in 70S ribosome – Cryo EM<BR />
**[[4v68]] – TtEF + antibiotic in 70S ribosome – Cryo EM<BR />
**[[2bvn]] - EcEF + GDP<BR />NP + antibiotic<BR />
**[[2bvn]] - EcEF + GDP<BR />NP + antibiotic<BR />
-
**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]] – EcEF + antibiotic
+
**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]] – EcEF + antibiotic
*''EF-Tu complex with nucleotide''
*''EF-Tu complex with nucleotide''
Line 66: Line 66:
**[[3wy9]] – PhEF + L12 <br />
**[[3wy9]] – PhEF + L12 <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
 +
**[[4zv4]] – PaEF + TSE6 - ''Pseudomonas aeruginosa''<br />
*''EF-Tu with EF-Ts''
*''EF-Tu with EF-Ts''
-
**[[1efu]], [[3agp]], [[3agq]] – EcEF + EcEF-Ts<BR />
+
**[[1efu]], [[3agp]], [[3agq]], [[4pc1]] – EcEF + EcEF-Ts<BR />
**[[3avt]], [[3avu]] , [[3avv]], [[3avw]], [[3avx]], [[3avy]], [[3vnu]] , [[3vnv]], [[4fwt]] – EcEF + EcEF-Ts + RNA<br />
**[[3avt]], [[3avu]] , [[3avv]], [[3avw]], [[3avx]], [[3avy]], [[3vnu]] , [[3vnv]], [[4fwt]] – EcEF + EcEF-Ts + RNA<br />
**[[3mmp]] – EcEF + EcEF-Ts + RNA replicase beta chain<br />
**[[3mmp]] – EcEF + EcEF-Ts + RNA replicase beta chain<br />
**[[4q7j]] – EcEF + EcEF-Ts + Q beta replicase + S1<br />
**[[4q7j]] – EcEF + EcEF-Ts + Q beta replicase + S1<br />
 +
**[[4r71]] – EcEF + EcEF-Ts + RNA polymerase β chain + S1<br />
 +
**[[4pc7]] – EcEF + EcEF-Ts + antibiotic + GNP<br />
 +
**[[4pc2]], [[4pc3]], [[4pc6]] – EcEF + EcEF-Ts + GDP derivative<br />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
**[[1xb2]] – bEF + EF-Ts - bovine<BR />
Line 109: Line 113:
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
**[[1pn6]], [[3izp]] – TtEF – Cryo EM<BR />
**[[1pn6]], [[3izp]] – TtEF – Cryo EM<BR />
-
**[[4v8u]] – TtEF in 70S ribosome <BR />
 
-
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
 
-
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
 
-
**[[4v9b]] – EcEF in 30S ribosome – Cryo-EM<BR />
 
-
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
 
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
Line 120: Line 119:
**[[2bv3]] - TtEF (mutant) + GTP analog<br />
**[[2bv3]] - TtEF (mutant) + GTP analog<br />
**[[2j7k]] - TtEF (mutant) + GDP analog<br />
**[[2j7k]] - TtEF (mutant) + GDP analog<br />
-
**[[2om7]], [[2wri]], [[2wrk]] – TtEF in 70S ribosome – Cryo EM<BR />
 
-
**[[4v5m]], [[4v5n]] - TtEF in 70S ribosome<BR />
 
**[[1dar]], [[2efg]] – TtEF + GDP<BR />
**[[1dar]], [[2efg]] – TtEF + GDP<BR />
**[[1jqm]], [[1jqs]] – EcEF + L11 – Cryo EM<BR />
**[[1jqm]], [[1jqs]] – EcEF + L11 – Cryo EM<BR />
-
**[[1zn0]], [[2rdo]], [[3j0e]], [[4v6t]] – EcEF in 30S ribosome – Cryo-EM<BR />
+
**[[4fn5]] – PaEF <br />
-
**[[4fn5]] – PaEF - ''Pseudomonas aeruginosa''<br />
+
**[[5tv2]] – EF – ''Vibrio vulnificus''<br />
 +
**[[5ty0]] – EF N terminal – ''Legionella pneumophila''<br />
 +
**[[5vh6]] – EF N terminal – ''Bacillus subtilis''<br />
 +
 
 +
*''EF-G in the ribosome''
 +
 
 +
**[[4v8u]], [[4v5m]], [[4v5n]] – TtEF in 70S ribosome <BR />
 +
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
 +
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
 +
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
 +
**[[2om7]], [[2wri]], [[2wrk]] – TtEF in 70S ribosome – Cryo EM<BR />
 +
**[[1zn0]], [[2rdo]], [[3j0e]], [[4v6t]], [[4v9b]] – EcEF in 30S ribosome – Cryo-EM<BR />
*EF-GreA/GreB
*EF-GreA/GreB
Line 147: Line 155:
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
 +
**[[5j3b]] – EF – ''Acinetobacter baumannii''<br />
*EF-Ts
*EF-Ts
Line 157: Line 166:
**[[2uz8]] – hEF (mutant)
**[[2uz8]] – hEF (mutant)
-
*EF-1 α-2
+
*EF-1
-
 
+
-
**[[4c0s]] – rEF – rabbit<br />
+
-
 
+
-
*EF-1 δ-1
+
-
 
+
-
**[[2mvm]], [[2mvn]] – hEF CAR domain – NMR<br />
+
-
 
+
-
*EF-1G
+
-
**[[1nhy]] – yEF N terminal
+
**[[4c0s]] – rEF α-2 – rabbit<br />
-
**[[1pbu]] – hEF C terminal (mutant) - NMR<BR />
+
**[[5dqs]] – hEF β+γ <br />
 +
**[[1nhy]] – yEF γ N terminal
 +
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
 +
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
*EF-2
*EF-2
Line 200: Line 204:
**[[1wsu]], [[2uwm]] – MtEF + RNA<BR />
**[[1wsu]], [[2uwm]] – MtEF + RNA<BR />
**[[2ply]] – MtEF (mutant) + RNA<BR />
**[[2ply]] – MtEF (mutant) + RNA<BR />
 +
**[[4zu9]] - AaEF <BR />
**[[4aca]] – MmEF – ''Methanococcus maripaludis''<BR />
**[[4aca]] – MmEF – ''Methanococcus maripaludis''<BR />
**[[4acb]] – MmEF + GTP analog<br />
**[[4acb]] – MmEF + GTP analog<br />
**[[4ac9]] – MmEF + GDP<BR />
**[[4ac9]] – MmEF + GDP<BR />
-
**[[2pjp]] – EcEF + RNA
+
**[[2pjp]] – EcEF + RNA<br />
 +
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
*EF-Spt5
*EF-Spt5

Revision as of 10:40, 27 April 2017

Structure of EF-Tu (cyan and magenta) with EF-Ts (green and yellow) (PDB entry 1efu)

Drag the structure with the mouse to rotate

3D structures of elongation factor

Updated on 27-April-2017

References

  1. ↑ Takeshita D, Tomita K. Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15733-8. Epub 2010 Aug 23. PMID:20798060 doi:http://dx.doi.org/10.1073/pnas.1006559107
  2. ↑ Jorgensen R, Merrill AR, Andersen GR. The life and death of translation elongation factor 2. Biochem Soc Trans. 2006 Feb;34(Pt 1):1-6. PMID:16246167 doi:http://dx.doi.org/10.1042/BST20060001
  3. ↑ Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R. The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature. 1996 Feb 8;379(6565):511-8. PMID:8596629 doi:http://dx.doi.org/10.1038/379511a0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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