Sandbox GGC2

Glucokinase is also known as human hexokinase IV. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Structure

Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a and a . When glucose molecule binds to the of glucoskinase, it forms hydrogen bonds with . At the , either glucokinase activators (GKA) or glucokinase inhibitor (GKI) will bind to regulate the activity of glucokinase by changing the confirmation. JSmol structure shows an example of GK-GKA complex, where the GKA bind to the allosteric site.

Function

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