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Sandbox GGC3

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== Structural highlights ==
== Structural highlights ==
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LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. <scene name='75/752266/Sheets_and_helices/1'>Chain A </scene> contains 10 anti-parallel ß-strands by 6 α-helices which defines the central cavity entrance. The TAG glyceryl group is located at the entrance and has a conserved orientation. At the cavity entrance the hydophilic glyceryl interacts with <scene name='75/752266/Sn3-chain/3'> Ser72 </scene>. There are three acyl chains bound within the cavity sn1, sn2, and sn3 and form interactions with hydrophobic residue side chains within the cavity. The third acyl chain is exposed to the solvent and the other two (sn1 and sn2) are buried and not shown. The sn3 chain is near two hydrophobic grooves, these grooves could facilitate the binding of TAG with other longer acyl chains.
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LprG (4ZRA) consists of two chains A and C containing alpha-beta folds. Chain A contains 10 anti-parallel ß-strands by 6 α-helices which defines the central cavity entrance. The TAG glyceryl group is located at the entrance and has a conserved orientation. At the cavity entrance the hydophilic glyceryl interacts with Ser72. There are three acyl chains bound within the cavity sn1, sn2, and sn3 and form interactions with hydrophobic residue side chains within the cavity. The third acyl chain is exposed to the solvent and the other two (sn1 and sn2) are buried and not shown. The sn3 chain is near two hydrophobic grooves, these grooves could facilitate the binding of TAG with other longer acyl chains.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Revision as of 22:45, 30 April 2017

Lipoprotein

Caption for this structure

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References

[3]

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351., eCollection 2016 Jan. PMID:26751071 doi:http://dx.doi.org/10.1371/journal.ppat.1005351
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