1v1j
From Proteopedia
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|PDB= 1v1j |SIZE=350|CAPTION= <scene name='initialview01'>1v1j</scene>, resolution 2.2Å | |PDB= 1v1j |SIZE=350|CAPTION= <scene name='initialview01'>1v1j</scene>, resolution 2.2Å | ||
|SITE= <scene name='pdbsite=DHQ:Trs+Binding+Site+For+Chain+K'>DHQ</scene> | |SITE= <scene name='pdbsite=DHQ:Trs+Binding+Site+For+Chain+K'>DHQ</scene> | ||
| - | |LIGAND= <scene name='pdbligand=FA3:2-ANHYDRO-3-FLUORO-QUINIC+ACID'>FA3</scene> | + | |LIGAND= <scene name='pdbligand=FA3:2-ANHYDRO-3-FLUORO-QUINIC+ACID'>FA3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v1j OCA], [http://www.ebi.ac.uk/pdbsum/1v1j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v1j RCSB]</span> | ||
}} | }} | ||
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[[Category: Lapthorn, A J.]] | [[Category: Lapthorn, A J.]] | ||
[[Category: Roszak, A W.]] | [[Category: Roszak, A W.]] | ||
| - | [[Category: FA3]] | ||
| - | [[Category: TRS]] | ||
[[Category: aromatic amino acid biosynthesis]] | [[Category: aromatic amino acid biosynthesis]] | ||
[[Category: dehydroquinase]] | [[Category: dehydroquinase]] | ||
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[[Category: shikimate]] | [[Category: shikimate]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:18:16 2008'' |
Revision as of 21:18, 30 March 2008
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| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Activity: | 3-dehydroquinate dehydratase, with EC number 4.2.1.10 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO
Overview
The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
About this Structure
1V1J is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.
Reference
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210
Page seeded by OCA on Mon Mar 31 00:18:16 2008
