6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3udv' size='340' side='right' caption='Structure of E. coli HPPK complex with inhibitor (green) (PDB code [[3udv]]).' scene='59/593854/Cv/1'> | + | <StructureSection load='3udv' size='340' side='right' caption='Structure of E. coli HPPK complex with inhibitor (green) (PDB code [[3udv]]).' scene='59/593854/Cv/1' pspeed='8'> |
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | Three loop regions surround the HPPK active site. Upon binding of ATP, the <scene name='59/593854/Cv/2'>flexible loops</scene> region (purple) changes its conformation and enables the binding of HMDP. <scene name='59/593854/Cv/ | + | Three loop regions surround the HPPK active site. Upon binding of ATP, the <scene name='59/593854/Cv/2'>flexible loops</scene> region (purple) changes its conformation and enables the binding of HMDP. <scene name='59/593854/Cv/4'>Active site: Y53, N55, D95, D97, E77, L111, H115, Y116, R121, F123</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 11:38, 8 May 2017
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3D structures of HPPK
Updated on 08-May-2017
References
- ↑ Xiao B, Shi G, Chen X, Yan H, Ji X. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Structure. 1999 May;7(5):489-96. PMID:10378268
