5vjc

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m (Protected "5vjc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5vjc is ON HOLD
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==TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation==
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<StructureSection load='5vjc' size='340' side='right' caption='[[5vjc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vjc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VJC FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vjc OCA], [http://pdbe.org/5vjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vjc RCSB], [http://www.ebi.ac.uk/pdbsum/5vjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vjc ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MSPS_DROME MSPS_DROME]] Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage. Involved in mitotic spindle elongation. Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts. Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd. Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization. Seems to be involved in elongation of kinetochore-derived microtubule fibers.<ref>PMID:10477755</ref> <ref>PMID:11433295</ref> <ref>PMID:15530399</ref> <ref>PMID:15775959</ref> <ref>PMID:16303556</ref> <ref>PMID:17889670</ref> <ref>PMID:26953351</ref> <ref>PMID:21965297</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Byrnes, A E]]
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[[Category: Slep, K C]]
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[[Category: Cell cycle]]
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[[Category: Heat repeat]]
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[[Category: Tog]]
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[[Category: Tubulin]]

Revision as of 13:02, 10 May 2017

TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation

5vjc, resolution 2.00Å

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