Fibroblast growth factor

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== Relevance ==
== Relevance ==
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FGF signaling is important in the pathogenesis of a variety of tumor types, angiogenesis and wound healing.
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FGF signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>.
== Structural insights ==
== Structural insights ==

Revision as of 10:25, 15 May 2017

Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code 2uus)

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3D structures of fibroblast growth factor

Updated on 15-May-2017

References

  1. Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol. 2001;2(3):REVIEWS3005. Epub 2001 Mar 9. PMID:11276432
  2. Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780. PMID:20094046 doi:http://dx.doi.org/10.1038/nrc2780
  3. Friesel RE, Maciag T. Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 1995 Jul;9(10):919-25. PMID:7542215
  4. Molloy T, Wang Y, Murrell G. The roles of growth factors in tendon and ligament healing. Sports Med. 2003;33(5):381-94. PMID:12696985
  5. Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M. Dimerization effect of sucrose octasulfate on rat FGF1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt, 6):448-52. Epub 2008 May 16. PMID:18540049 doi:10.1107/S174430910801066X

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Michal Harel, Alexander Berchansky

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