5hpp
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpp OCA], [http://pdbe.org/5hpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpp RCSB], [http://www.ebi.ac.uk/pdbsum/5hpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpp OCA], [http://pdbe.org/5hpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpp RCSB], [http://www.ebi.ac.uk/pdbsum/5hpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | High-resolution structures of peptide supramolecular assemblies are key to understanding amyloid diseases and designing peptide-based materials. This paper explores the supramolecular assembly of a macrocyclic beta-sheet peptide derived from transthyretin (TTR). The peptide mimics the beta-hairpin formed by the beta-strands G and H of TTR, which form the interface of the TTR tetramer. X-ray crystallography reveals that the peptide does not form a tetramer, but rather assembles to form square channels. The square channels are formed by extended networks of beta-sheets and pack in a "tilted windows" pattern. This unexpected structure represents an emergent property of the peptide and broadens the scope of known supramolecular assemblies of beta-sheets. | ||
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| + | Square channels formed by a peptide derived from transthyretin.,Yoo S, Kreutzer AG, Truex NL, Nowick JS Chem Sci. 2016 Dec 1;7(12):6946-6951. doi: 10.1039/c6sc01927g. Epub 2016 Aug 1. PMID:28451128<ref>PMID:28451128</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5hpp" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:11, 17 May 2017
Crystal structure of a macrocyclic beta-sheet peptide derived from transthyretin (106-121) - (ORN)TIA(MAA)LLS(ORN)S(PHI)STTAV
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