Folylpolyglutamate synthase

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*Folypolyglutamate synthase
*Folypolyglutamate synthase
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**[[3nrs]] – YpFPGS/dihydrofolate synthase – Yersinia pestis <BR />
+
**[[3nrs]] – YpFPGS/dihydrofolate synthase – ''Yersinia pestis'' <BR />
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**[[1o5z]] – FPGS – Thermotoga maritima <BR />
+
**[[1o5z]] – FPGS – ''Thermotoga maritima'' <BR />
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**[[2gca]] – LcFPGS – Lactobacillus casei <BR />
+
**[[2gca]] – LcFPGS – ''Lactobacillus casei'' <BR />
*Folypolyglutamate synthase complex
*Folypolyglutamate synthase complex
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**[[3pyz]] – YpFPGS/dihydrofolate synthase + AMPPNP + Mn <BR />
**[[3pyz]] – YpFPGS/dihydrofolate synthase + AMPPNP + Mn <BR />
**[[3n2a]] – YpFPGS/dihydrofolate synthase + ADP + Mg <BR />
**[[3n2a]] – YpFPGS/dihydrofolate synthase + ADP + Mg <BR />
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**[[2vor]] – MtFPGS + ADP + AMPPNP – Mycobacterium tuberculosis <BR />
+
**[[2vor]] – MtFPGS + ADP + AMPPNP – ''Mycobacterium tuberculosis'' <BR />
**[[2vos]] – MtFPGS + ADP <BR />
**[[2vos]] – MtFPGS + ADP <BR />
**[[2gc5]], [[2gc6]], [[2gcb]] – FPGS (mutant) <BR />
**[[2gc5]], [[2gc6]], [[2gcb]] – FPGS (mutant) <BR />
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**[[1w78]] – EcFPGS + ADP + DHPP – Escherichia coli <BR />
+
**[[1w78]] – EcFPGS + ADP + DHPP – ''Escherichia coli'' <BR />
**[[1w7k]] – EcFPGS + ADP <BR />
**[[1w7k]] – EcFPGS + ADP <BR />
**[[1jbv]] – LcFPGS + AMPPCP <BR />
**[[1jbv]] – LcFPGS + AMPPCP <BR />

Revision as of 10:06, 18 May 2017

Folypolyglutamate synthase complex with AMPPCP and Co+2 ion (pink) (PDB code 2vor)

Drag the structure with the mouse to rotate

3D structures of folypolyglutamate synthase

Updated on 18-May-2017

References

  1. ↑ Kim SE, Hinoue T, Kim MS, Sohn KJ, Cho RC, Weisenberger DJ, Laird PW, Kim YI. Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. J Nutr Biochem. 2016 Mar;29:27-35. doi: 10.1016/j.jnutbio.2015.10.019. Epub 2015 , Nov 17. PMID:26895662 doi:http://dx.doi.org/10.1016/j.jnutbio.2015.10.019
  2. ↑ Piwkham D, Siriboonpiputtana T, Beuten J, Pakakasama S, Gelfond JA, Paisooksantivatana K, Tomlinson GE, Rerkamnuaychoke B. Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia. Asian Pac J Cancer Prev. 2015;16(11):4727-32. PMID:26107232
  3. ↑ Sohn KJ, Smirnakis F, Moskovitz DN, Novakovic P, Yates Z, Lucock M, Croxford R, Kim YI. Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. Gut. 2004 Dec;53(12):1825-31. PMID:15542523 doi:http://dx.doi.org/10.1136/gut.2004.042713
  4. ↑ Young PG, Smith CA, Metcalf P, Baker EN. Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP. Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):745-53. Epub 2008, Jun 18. PMID:18566510 doi:http://dx.doi.org/10.1107/S0907444908012262
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