Glycosyltransferase

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Line 103: Line 103:
**[[2vce]] – AtGT – ''Arabidopsis thaliana''<br />
**[[2vce]] – AtGT – ''Arabidopsis thaliana''<br />
**[[2vch]], [[2vg8]] – AtGT + UDP
**[[2vch]], [[2vg8]] – AtGT + UDP
 +
 +
*UDP GT
 +
 +
**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
 +
**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
*Flavonoid GT
*Flavonoid GT
Line 119: Line 124:
**[[4mnr]] – GT D,D transpeptidase domain – ''Eggerthella lenta''<br />
**[[4mnr]] – GT D,D transpeptidase domain – ''Eggerthella lenta''<br />
**[[4n1x]], [[4qjg]], [[4r1g]], [[4r23]], [[4r3j]], [[4ra7]] – ApGT penicillin-binding domain + penicillin<br />
**[[4n1x]], [[4qjg]], [[4r1g]], [[4r23]], [[4r3j]], [[4ra7]] – ApGT penicillin-binding domain + penicillin<br />
-
**[[4qjg]] – ApGT penicillin-binding domain + antibiotic<br />
+
**[[4qjg]], [[rr0q]] – ApGT penicillin-binding domain + antibiotic<br />
 +
**[[5uy7]] – GT – ''Burkholderia ambifaria''<br />
*Various GT
*Various GT
- 
-
**[[1nzd]] – T4β-GT + UDP-glucose – Phage T4
 
- 
-
**[[2nzf]], [[1nzf]] - T4β-GT (mutant) + UDP-glucose
 
**[[2iuy]], [[2iv3]] – SvGT – ''Stretptomyces viridochromogenes''
**[[2iuy]], [[2iv3]] – SvGT – ''Stretptomyces viridochromogenes''
**[[3hzs]], [[3vmq]] – SaGT – ''Staphylococcus aureus''<br />
**[[3hzs]], [[3vmq]] – SaGT – ''Staphylococcus aureus''<br />
-
**[[3vmr]], [[3vms]], [[3vmt]] – SaGT + lipid II analog<br />
+
**[[2jjm]] - BaGT – ''Bacillus anthracis''<br />
-
**[[3mbo]] – BaGT + UDP + malate – ''Bacillus anthracis''
+
-
 
+
-
**[[2jjm]] - BaGT<br />
+
**[[3oy2]] – PcvGT – ''Paramecium chiorela virus''<br />
**[[3oy2]] – PcvGT – ''Paramecium chiorela virus''<br />
-
**[[3oy7]] – PcvGT + GDP-mannose
 
**[[3pnn]] – GT – ''Porphyromonas gingivalis''
**[[3pnn]] – GT – ''Porphyromonas gingivalis''
Line 141: Line 139:
**[[2q3e]], [[3q3i]], [[3q3e]] – ApGT – ''Actinobacillus pleuropneumomiae''
**[[2q3e]], [[3q3i]], [[3q3e]] – ApGT – ''Actinobacillus pleuropneumomiae''
-
**[[3q3h]] – ApGT + UDP-Glc
+
**[[1iir]] – AoUDP-GT – ''Amycolatopsis orientalis''
-
 
+
-
**[[1iir]] – AoUDP-GT – ''Amycolatopsis orientali''s
+
-
 
+
-
**[[1pn3]], [[1pnv]], [[1rrv]] – AoGT + TDP + vancomycin
+
-
 
+
-
**[[2yjn]] – GT + Dtpd-4-keto-6-deoxy-hexose isomerase – ''Saccharopolyspora erythraea''
+
**[[3h4i]], [[3h4t]] – GT chimera
**[[3h4i]], [[3h4t]] – GT chimera
Line 154: Line 146:
**[[2iv7]], [[2iw1]], [[4rap]] – EcGT - ''Escherichia coli''<br />
**[[2iv7]], [[2iw1]], [[4rap]] – EcGT - ''Escherichia coli''<br />
-
**[[4rb4]] – EcGT (mutant) + ADP-heptose<br />
+
**[[4xyw]] – EcGT (mutant) <br />
**[[2xci]] – AaGT – ''Aquifex aeolicus''
**[[2xci]] – AaGT – ''Aquifex aeolicus''
- 
-
**[[2xcu]] – AaGT + CMP
 
**[[3ia7]] – MeGT Calg4 – ''Micromonospora echinospora''
**[[3ia7]] – MeGT Calg4 – ''Micromonospora echinospora''
 +
**[[3otk]] – GT catalytic domain - mouse<br />
 +
**[[4ayl]] - BoGT – ''Bacterioides ovatus''<br />
 +
**[[4an4]], [[4amb]], [[4amg]] – GT Snogd – ''Streptomyces nogalater''<br />
 +
**[[3wad]] – ShGT – ''Streptomyces halstedii''<br />
 +
**[[4pqg]] – GT- ''Streptococcus pneumoniae''<br />
 +
**[[5du2]] - GT – ''Actinomadura verrucosospora''<br />
 +
**[[5a01]] – DmO-GT catalytic domain (mutant) – ''Drosophila melanogaster''<br />
 +
 +
*Various GT complexes
 +
 +
**[[1nzd]] – T4β-GT + UDP-glucose – Phage T4
 +
 +
**[[2nzf]], [[1nzf]] - T4β-GT (mutant) + UDP-glucose<br />
 +
**[[3vmr]], [[3vms]], [[3vmt]] – SaGT + lipid II analog<br />
 +
**[[3mbo]] – BaGT + UDP + malate <br />
 +
**[[3oy7]] – PcvGT + GDP-mannose <br />
 +
**[[3q3h]] – ApGT + UDP-Glc<br />
 +
**[[1pn3]], [[1pnv]], [[1rrv]] – AoGT + TDP + vancomycin<br />
 +
**[[4rb4]] – EcGT (mutant) + ADP-heptose<br />
 +
**[[2yjn]] – GT + Dtpd-4-keto-6-deoxy-hexose isomerase – ''Saccharopolyspora erythraea''<br />
 +
**[[2xcu]] – AaGT + CMP<br />
**[[3iaa]] – MeGT Calg2 + TDP
**[[3iaa]] – MeGT Calg2 + TDP
-
**[[3rsc]] - MeGT Calg2 + TDP + calicheamicin
+
**[[3rsc]] - MeGT Calg2 + TDP + calicheamicin<br />
-
 
+
**[[4ayj]] – BoGT + glucose + galactose + fucose <br />
-
**[[3otk]] – GT catalytic domain - mouse<br />
+
-
**[[4ayj]] – BoGT + glucose + galactose + fucose – ''Bacterioides ovatus''<br />
+
**[[4cj8]], [[4cjc]] - BoGT (mutant) + UDP + galactosamine + UDP-galactosamine <br />
**[[4cj8]], [[4cjc]] - BoGT (mutant) + UDP + galactosamine + UDP-galactosamine <br />
**[[4cjb]] - BoGT (mutant) + GalNac <br />
**[[4cjb]] - BoGT (mutant) + GalNac <br />
-
**[[4ayl]] - BoGT<br />
 
**[[1g9r]] - GT (mutant) + UDP-galactose + Mn – ''Neisseria meningitides''<br />
**[[1g9r]] - GT (mutant) + UDP-galactose + Mn – ''Neisseria meningitides''<br />
-
**[[4an4]], [[4amb]], [[4amg]] – GT Snogd – ''Streptomyces nogalater''<br />
 
-
**[[3wad]] – ShGT – ''Streptomyces halstedii''<br />
 
**[[3wag]] – ShGT + DTDP<br />
**[[3wag]] – ShGT + DTDP<br />
-
**[[4pqg]] – GT- ''Streptococcus pneumoniae''<br />
+
**[[5tme]], [[5tmb]] – rGT + UDP - rice<br />
 +
**[[5tmd]] – rGT + UDP derivative + trichothecene<br />
 +
**[[5gl5]] - GT + UDP-glucose – yeast<br />
 +
**[[5ekp]] - SyGT + UDP – ''Synechosystis''<br />
 +
**[[5eke]] - SyGT (mutant) + UDP <br />
 +
**[[5e9u]], [[5e9t]] - GT + UDP + GlcNac + GT chaperone – ''Streptococcus gordonii''<br />
*β-1,4-galactosyltransferase (BGT)
*β-1,4-galactosyltransferase (BGT)
Line 181: Line 192:
**[[1pzt]] - bBGT catalytic domain (mutant) <br />
**[[1pzt]] - bBGT catalytic domain (mutant) <br />
**[[2fy7]] - hBGT catalytic domain (mutant) <br />
**[[2fy7]] - hBGT catalytic domain (mutant) <br />
-
**[[3lw6]] - BGT catalytic domain (mutant) – ''Drosophila melanogaster''
+
**[[3lw6]] - DmBGT catalytic domain (mutant)
*''BGT binary complexes''
*''BGT binary complexes''

Revision as of 08:08, 4 June 2017

Cyclodextrin glycosyltransferase complex with substrate maltoheptaose, maltose and Ca+2 ions, 1cxh

Drag the structure with the mouse to rotate

3D structures of glycosyltransferase

Updated on 04-June-2017

References

  1. ↑ Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
  2. ↑ Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
  3. ↑ Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943
  4. ↑ Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell. 2001 Nov;1(5):717-24. PMID:11709191
  5. ↑ Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. J Biol Chem. 1995 Dec 8;270(49):29256-64. PMID:7493956

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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