Lysine-specific histone demethylase

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Line 21: Line 21:
**[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br />
**[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br />
 +
**[[5it3]] - hLSD1 SWIRM domain<br />
**[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br />
**[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br />
**[[2hko]] – hLSD1 (mutant)<br />
**[[2hko]] – hLSD1 (mutant)<br />
Line 33: Line 34:
**[[2iw5]], [[2uxn]], [[2uxx]] - hLSD1 SWIRM + amine oxidase domains + CoREST SANT1 and SANT2 domains<br />
**[[2iw5]], [[2uxn]], [[2uxx]] - hLSD1 SWIRM + amine oxidase domains + CoREST SANT1 and SANT2 domains<br />
-
**[[2v1d]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 2-22 (mutant)<br />
+
**[[2v1d]], [[5x60]], [[5h6r]], [[5h6q]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 2-22 (mutant)<br />
**[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br />
**[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br />
**[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br />
**[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br />
Line 41: Line 42:
**[[4kum]] - hLSD1 SWIRM + FAD domains + CoREST residues 289-485 <br />
**[[4kum]] - hLSD1 SWIRM + FAD domains + CoREST residues 289-485 <br />
**[[4czz]] - hLSD1 + CoREST <br />
**[[4czz]] - hLSD1 + CoREST <br />
-
**[[4uv8]], [[4uv9]], [[4uva]], [[4uvb]], [[4ubc]] - hLSD1 + CoREST + irreversible inhibitor<br />
+
**[[5l3b]], [[5l3c]], [[5l3d]], - hLSD1 (mutant) + CoREST <br />
 +
**[[4uv8]], [[4uv9]], [[4uva]], [[4uvb]], [[4uvc]] - hLSD1 + CoREST + irreversible inhibitor<br />
 +
**[[5l3e]], [[5lbq]], [[5lgn]], [[5lgt]], [[5lgu]], [[5lhg]], [[5lhh]], [[5lhi]] - hLSD1 + CoREST + reversible inhibitor<br />
 +
**[[5l3f]], [[5l3g]] - hLSD1 + CoREST + polmyxin peptide<br />
 +
**[[4xbf]] - hLSD1 + CoREST + RNA<br />
**[[4uxn]] - hLSD1 + CoREST + pyrrolydine inhibitor<br />
**[[4uxn]] - hLSD1 + CoREST + pyrrolydine inhibitor<br />
Line 51: Line 56:
**[[4guu]] – hLSD2 + NPAC + tranylcypromine <br />
**[[4guu]] – hLSD2 + NPAC + tranylcypromine <br />
**[[4gu0]] – hLSD2 + histone 3.3 peptide <br />
**[[4gu0]] – hLSD2 + histone 3.3 peptide <br />
- 
-
*lysine-specific demethylase 4A or JMJD2A see [[Jumonji domain-containing protein]]
 
- 
-
*lysine-specific demethylase 4D or KDM4D
 
- 
-
**[[5fp7]], [[5fp4]], [[5fp8]], [[5fp9]], [[5fpa]], [[5fpb]], [[5f5c]], [[5f5i]], [[5f5a]] – hLSD4D + inhibitor<br />
 
- 
-
*lysine-specific demethylase 5A or KDM5A or JARID1A
 
- 
-
**[[5k4l]], [[5ceh]] – hLSD5A + inhibitor + peptide<br />
 
-
**[[5c11]] – hLSD5A PHD finger + histone peptide<br />
 
-
**[[5isl]], [[5ivc]], [[5ive]], [[5ivf]], [[5ivj]], [[5ivv]], [[5ivy]], [[5iw0]], [[5iwf]] – hLSD5A Jmj domain + inhibitor <br />
 
-
**[[5ivb]], [[5e6h]] – hLSD5A Jmj domain + a-ketoglutarate<br />
 
-
**[[2kgg]] – hLSD5A PHD finger - NMR<br />
 
-
**[[2kgi]] – hLSD5A PHD finger + histone peptide - NMR<br />
 
-
**[[3gl6]] – hLSD5A PHD finger + histone peptide <br />
 
-
**[[2jxj]] – hLSD5A ARID domain - NMR<br />
 
*lysine-specific histone demethylase 5B or JARID1B or KDM5B
*lysine-specific histone demethylase 5B or JARID1B or KDM5B
Line 80: Line 68:
**[[5fup]] – hLSD5B + oxoglutarate<br />
**[[5fup]] – hLSD5B + oxoglutarate<br />
**[[5fv3]], [[5a1f]] – hLSD5B + oxalyl glycine<br />
**[[5fv3]], [[5a1f]] – hLSD5B + oxalyl glycine<br />
- 
-
*lysine-specific demethylase 5C or JARID1C or KDM5C
 
- 
-
**[[5fwj]] – hLSD5C Jmj domain + inhibitor<br />
 
-
**[[2jrz]] – hLSD5C Bright/ARID domain - NMR<br />
 
- 
-
*lysine-specific demethylase 5D or JARID1D
 
- 
-
**[[2yqe]] – hLSD5D ARID domain - NMR<br />
 
- 
-
*lysine-specific demethylase 6B or JMJD3 see [[Jumonji domain-containing protein]]
 
}}
}}

Revision as of 09:02, 5 July 2017

Human FAD-containing LSD1 (cyan) complex with CoREST (green) and histone H3 helix (deeppink), 2v1d

Drag the structure with the mouse to rotate

3D structures of lysine-specific histone demethylase

Updated on 05-July-2017

References

  1. ↑ Chen Y, Jie W, Yan W, Zhou K, Xiao Y. Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr. 2012;22(1):53-9. PMID:22339659
  2. ↑ Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May, 10. PMID:22533360 doi:http://dx.doi.org/10.1021/cb300108c
  3. ↑ van Essen D, Zhu Y, Saccani S. A feed-forward circuit controlling inducible NF-kappaB target gene activation by promoter histone demethylation. Mol Cell. 2010 Sep 10;39(5):750-60. doi: 10.1016/j.molcel.2010.08.010. PMID:20832726 doi:http://dx.doi.org/10.1016/j.molcel.2010.08.010
  4. ↑ Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7096-101. doi:, 10.1073/pnas.1324036111. Epub 2014 Apr 28. PMID:24778210 doi:http://dx.doi.org/10.1073/pnas.1324036111
  5. ↑ Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976

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