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5ulp
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ulp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ulp OCA], [http://pdbe.org/5ulp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ulp RCSB], [http://www.ebi.ac.uk/pdbsum/5ulp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ulp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ulp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ulp OCA], [http://pdbe.org/5ulp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ulp RCSB], [http://www.ebi.ac.uk/pdbsum/5ulp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ulp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2'OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses. | ||
| + | |||
| + | Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.,Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. PMID:28487506<ref>PMID:28487506</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ulp" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:03, 3 August 2017
Structure of the NS5 methyltransferase from Zika bound to MS2042
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Categories: Aggarwal, A K | Jain, R | Flavivirus | Hydrolase | Methyltransferase | Ms2042 | Ns5 | Sam analog | Zika
