Nuclear receptor coactivator
From Proteopedia
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| - | + | <StructureSection load='1oj5' size='400' side='right' scene='' caption='Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]]'> | |
'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br /> | '''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br /> | ||
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*'''NCOA3''' shows histone acetyltransferase activity.<br /> | *'''NCOA3''' shows histone acetyltransferase activity.<br /> | ||
*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | *'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | ||
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==3D structures of nuclear receptor coactivator== | ==3D structures of nuclear receptor coactivator== | ||
Revision as of 09:29, 22 August 2017
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3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
