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P63

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*<scene name='70/706258/Cv/3'>A-B dimer interactions with DNA</scene>.
*<scene name='70/706258/Cv/3'>A-B dimer interactions with DNA</scene>.
*<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>.
*<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>.
 +
^<scene name='70/706258/Cv/6'>Zn coordination site</scene>.
</StructureSection>
</StructureSection>
== 3D Structures of P63 ==
== 3D Structures of P63 ==

Revision as of 13:23, 23 August 2017

P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code 3us0)

Drag the structure with the mouse to rotate

3D Structures of P63

Updated on 23-August-2017

References

  1. ↑ Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:http://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
  2. ↑ Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
  3. ↑ Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
  4. ↑ Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:http://dx.doi.org/10.4161/cc.6.3.3792
  5. ↑ Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:http://dx.doi.org/10.1002/jcp.20829

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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