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Nitroreductase

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Line 19: Line 19:
**[[1f5v ]], [[1oo5]] – EcNR – ''Escherichia coli''<br />
**[[1f5v ]], [[1oo5]] – EcNR – ''Escherichia coli''<br />
 +
**[[3x21]], [[3x22]] – EcNR (mutant)<br />
**[[3bm1]], [[1ds7]] – EcNR minimal<br />
**[[3bm1]], [[1ds7]] – EcNR minimal<br />
**[[3bm2]] – EcNR minimal -FMN<br />
**[[3bm2]] – EcNR minimal -FMN<br />
Line 39: Line 40:
**[[3ge6]] – NR – ''Exiguobacterium sibiricum''<br />
**[[3ge6]] – NR – ''Exiguobacterium sibiricum''<br />
**[[4dn2]] – NR – ''Geobacter metallireducens''<br />
**[[4dn2]] – NR – ''Geobacter metallireducens''<br />
 +
**[[5ko7]], [[5ko8]], [[5krd]] – NR – ''Haliscomenobacter hydrossis''<br />
*Copper-induced nitroreductase
*Copper-induced nitroreductase
Line 50: Line 52:
*Nitroreductase binary complex
*Nitroreductase binary complex
-
**[[1kqb]] – EclNR + benzoate<br />
+
**[[1kqb]], [[5j8g]]– EclNR + benzoate derivative<br />
**[[1kqc]] – EclNR + acetate<br />
**[[1kqc]] – EclNR + acetate<br />
**[[1ylr]], [[1ylu]] - EcNR + acetate<br />
**[[1ylr]], [[1ylu]] - EcNR + acetate<br />
-
**[[1icr]], [[1icu]], [[1icv]] – EcNR + nicotinic acid<br />
+
**[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + NAD derivative<br />
**[[1ooq]] – EcNR + dicoumarol<br />
**[[1ooq]] – EcNR + dicoumarol<br />
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + benzamide derivative<br />
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + benzamide derivative<br />

Revision as of 10:21, 24 August 2017

E. coli nitroreductase dimer containing FMN and nicotinic acid (PDB entry 1icr)

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3D structures of nitroreductase

Updated on 24-August-2017

References

  1. ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
  2. ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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