Plasminogen activator

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Treatment with tissue PLA for acute ischemic stroke is beneficial<ref>PMID:7477192</ref>.
Treatment with tissue PLA for acute ischemic stroke is beneficial<ref>PMID:7477192</ref>.
== Structural highlights ==
== Structural highlights ==
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*<scene name='47/476004/Cv/2'>Interactions between tissue plasminogen activator light chain catalytic domain and heavy chain catalytic domain fragment</scene>. Water molecules shown as red spheres.
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*<scene name='47/476004/Cv/3'>Benzamidine binding site</scene>.
</StructureSection>
</StructureSection>
==3D structures of plasminogen activator==
==3D structures of plasminogen activator==

Revision as of 11:49, 3 September 2017

Human tissue plasminogen activator light chain catalytic domain (sky blue and green), heavy chain catalytic domain fragment (yellow and pink) complex with benzamidine, 1a5h

Drag the structure with the mouse to rotate

3D structures of plasminogen activator

Updated on 03-September-2017


References

  1. ↑ Sodeinde OA, Sample AK, Brubaker RR, Goguen JD. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun. 1988 Oct;56(10):2749-52. PMID:2843471
  2. ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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