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Plexin

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<StructureSection load='3nvn' size='400' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
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<StructureSection load='3nvn' size='450' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
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== Structural highlights ==
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*<scene name='46/466532/Cv/2'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules shown as red spheres.
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*<scene name='46/466532/Cv/3'>Ca coordination site</scene>.
</StructureSection>
</StructureSection>
==3D structures of plexin==
==3D structures of plexin==

Revision as of 10:23, 4 September 2017

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

3D structures of plexin

04-September-2017

References

  1. ↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
  2. ↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
  3. ↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200

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