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S100 protein

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<StructureSection load='2rgi' size='350' side='right' scene='' caption='Human S-100A2 complex with isopropanol and Na+ ion (PDB code [[2rgi]])'>
<StructureSection load='2rgi' size='350' side='right' scene='' caption='Human S-100A2 complex with isopropanol and Na+ ion (PDB code [[2rgi]])'>
== Function ==
== Function ==
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**[[2k2f]] – rCBP-1 + Ca + ryanodine receptor peptide - NMR<br />
**[[2k2f]] – rCBP-1 + Ca + ryanodine receptor peptide - NMR<br />
**[[2kbm]] – rCBP-1 + F-actin capping protein peptide - NMR<br />
**[[2kbm]] – rCBP-1 + F-actin capping protein peptide - NMR<br />
-
**[[1zfs]], [[2lp2]] – hCBP-1 + Ca – human - NMR<br />
+
**[[1zfs]], [[2lp2]], [[2lp3]], [[2l0p]] – hCBP-1 + Ca – human - NMR<br />
-
**[[2l0p]], [[2lp3]] – hCBP-1 + Ca - NMR<br />
+
**[[5k89]] – hCBP-1 + Ca <br />
**[[2lux]] - hCBP-1 (mutant) + Ca - NMR<br />
**[[2lux]] - hCBP-1 (mutant) + Ca - NMR<br />
**[[2lhl]], [[2lls]], [[2m3w]] – hCBP-1 (mutant) - NMR<br />
**[[2lhl]], [[2lls]], [[2m3w]] – hCBP-1 (mutant) - NMR<br />
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**[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br />
**[[3c1v]], [[3cga]], [[3ko0]], [[4hsz]] – hCBP-4 + Ca <br />
**[[3m0w]] – hCBP-4 + Ca + PCP<br />
**[[3m0w]] – hCBP-4 + Ca + PCP<br />
 +
**[[5lpu]] – hCBP-4 + Ca + annexin A2<br />
**[[3zwh]], [[4cfq]], [[4cfr]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br />
**[[3zwh]], [[4cfq]], [[4cfr]] – hCBP-4 (mutant) + Ca + myosin-9 peptide<br />
**[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br />
**[[4eto]] – hCBP-4 + Ca + myosin-9 peptide<br />
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**[[1k96]], [[1k9k]] – hCBP-6 + Ca <br />
**[[1k96]], [[1k9k]] – hCBP-6 + Ca <br />
**[[2m1k]] – hCBP-6 (mutant) + RAGE receptor - NMR <br />
**[[2m1k]] – hCBP-6 (mutant) + RAGE receptor - NMR <br />
-
**[[4p2y]] – hCBP-6 + RAGE receptor + Ca + Zn <br />
+
**[[4p2y]], [[4ybh]] – hCBP-6 + RAGE receptor + Ca + Zn <br />
*S100-A7 (Psoriasin)
*S100-A7 (Psoriasin)
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**[[1mr8]] – hCBP-8 + Ca <br />
**[[1mr8]] – hCBP-8 + Ca <br />
-
**[[1irj]] – hCBP-9 + Ca <br />
+
**[[5hlo]], [[5hlv]] – hCBP-8 + Ca + Zn <br />
-
**[[1xk4]] – hCBP-8 (mutant) + Ca + hCBP-9 (mutant) <br />
+
**[[1xk4]] – hCBP-8 (mutant) + hCBP-9 (mutant) + Ca <br />
**[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br />
**[[4ggf]] – hCBP-8 + hCBP-9 + Ca + Mn <br />
-
**[[4xgk]] – hCBP-8 (mutant) + hCBP-9 (mutant) + Ca + Mn <br />
+
**[[5w1f]] – hCBP-8 (mutant) + hCBP-9 (mutant) + Ni + Ca <br />
 +
**[[4xjk]] – hCBP-8 (mutant) + hCBP-9 (mutant) + Ca + Mn <br />
 +
 
*S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14)
*S100-A9 (Calgranulin-B or Migration inhibitory factor-related protein 14)
**[[1xk4]] – hCPB-9 (mutant) + hCBP-8 (mutant) + Ca <br />
**[[1xk4]] – hCPB-9 (mutant) + hCBP-8 (mutant) + Ca <br />
-
**[[4ggf]] – hCPB-9 + hCBP-8 + Ca + Mn<br />
+
**[[5i8n]] – hCPB-9 (mutant) - NMR <br />
**[[1irj]] – hCBP-9 + Ca <br />
**[[1irj]] – hCBP-9 + Ca <br />
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**[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br />
**[[1mho]], [[3cr4]], [[3gk1]], [[3gk2]], [[3gk4]], [[3iqo]], [[3lk0]], [[3lk1]], [[3lle]], [[3rlz]] – bCBP + Ca <br />
**[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br />
**[[3cr2]], [[3cr5]] – bCBP + Zn + Ca <br />
-
**[[4pdz]], [[4pe0]], [[4pe1]], [[4pe4]], [[4pe7]] – bCBP + Ca + inhibitor<br />
+
**[[4pdz]], [[4pe0]], [[4pe1]], [[4pe4]], [[4pe7]], [[5dkn]], [[5dkq]], [[5dkr]], [[5er4]], [[5er5]] – bCBP + Ca + inhibitor<br />
**[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br />
**[[4fqo]] – bCBP (mutant) + Ca + inhibitor<br />
**[[1uwo]], [[2pru]] – hCBP - NMR <br />
**[[1uwo]], [[2pru]] – hCBP - NMR <br />
**[[2h61]], [[3hcm]] – hCBP + Ca <br />
**[[2h61]], [[3hcm]] – hCBP + Ca <br />
-
**[[4xyn]] – hCBP + Ca + RAGE peptide <br />
+
**[[4xyn]], [[5d7f]] – hCBP + Ca + RAGE peptide <br />
**[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br />
**[[3czt]], [[3d0y]], [[3d10]] – hCBP + Zn + Ca <br />
**[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br />
**[[2m49]] – hCBP + fibroblast growth factor 2 - NMR<br />
 +
**[[5csi]], [[5csj]], [[5csn]], [[5csf]] – hCBP subunit β + ribosomal protein S6 kinase α-1 peptide + Ca <br />
*Calbindin D9k (S100G)
*Calbindin D9k (S100G)
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**[[2y5i]] – CBP + Ca - zebrafish <br />
**[[2y5i]] – CBP + Ca - zebrafish <br />
 +
**[[5hyd]] – hCBP <br />
}}
}}
== References ==
== References ==

Revision as of 19:51, 2 October 2017

Human S-100A2 complex with isopropanol and Na+ ion (PDB code 2rgi)

Drag the structure with the mouse to rotate

3D Structures of S100 proteins

Updated on 02-October-2017


References

  1. ↑ Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ, Geczy CL. Functions of S100 proteins. Curr Mol Med. 2013 Jan;13(1):24-57. PMID:22834835
  2. ↑ Yao R, Lopez-Beltran A, Maclennan GT, Montironi R, Eble JN, Cheng L. Expression of S100 protein family members in the pathogenesis of bladder tumors. Anticancer Res. 2007 Sep-Oct;27(5A):3051-8. PMID:17970044
  3. ↑ Wilsmann-Theis D, Wagenpfeil J, Holzinger D, Roth J, Koch S, Schnautz S, Bieber T, Wenzel J. Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity. J Eur Acad Dermatol Venereol. 2016 Jul;30(7):1165-70. doi: 10.1111/jdv.13269., Epub 2015 Sep 2. PMID:26333514 doi:http://dx.doi.org/10.1111/jdv.13269
  4. ↑ Zhu L, Okano S, Takahara M, Chiba T, Tu Y, Oda Y, Furue M. Expression of S100 protein family members in normal skin and sweat gland tumors. J Dermatol Sci. 2013 Jun;70(3):211-9. doi: 10.1016/j.jdermsci.2013.03.002. Epub, 2013 Mar 16. PMID:23623205 doi:http://dx.doi.org/10.1016/j.jdermsci.2013.03.002
  5. ↑ Bertini I, Borsi V, Cerofolini L, Das Gupta S, Fragai M, Luchinat C. Solution structure and dynamics of human S100A14. J Biol Inorg Chem. 2012 Nov 30. PMID:23197251 doi:10.1007/s00775-012-0963-3
  6. ↑ Babini E, Bertini I, Borsi V, Calderone V, Hu X, Luchinat C, Parigi G. Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 2010 Nov 3. PMID:21046186 doi:10.1007/s00775-010-0721-3

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