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Siderocalin

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<StructureSection load='1x89' size='450' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' >
<StructureSection load='1x89' size='450' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' >
== Function ==
== Function ==
-
'''Siderocalin''' (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>.
+
'''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>.
== Relevance ==
== Relevance ==
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*Siderocalin or lipocalin-2
*Siderocalin or lipocalin-2
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**[[5jr8]], [[3bx8]] – hScn NGAL - human<br />
+
**[[5jr8]], [[3bx8]], [[5khp]], [[5kid]], [[5kic]] – hScn NGAL - human<br />
**[[3s26]] – mScn NGAL - mouse<br />
**[[3s26]] – mScn NGAL - mouse<br />
**[[2kt4]] – qScn Q83 – quail<br />
**[[2kt4]] – qScn Q83 – quail<br />
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*Siderocalin complex
*Siderocalin complex
-
**[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + beta amyloid protein 40 peptide<br />
+
**[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + β-amyloid protein 40 peptide<br />
**[[3bx7]] – hScn NGAL + CTLA-4<br />
**[[3bx7]] – hScn NGAL + CTLA-4<br />
**[[3tzs]] – hScn NGAL (mutant) + phenylurea<br />
**[[3tzs]] – hScn NGAL (mutant) + phenylurea<br />

Revision as of 22:49, 3 October 2017

Human siderocalin complex with the siderophore carboxymycobactin (PDB code 1x89)

Drag the structure with the mouse to rotate

3D structures of siderocalin

Updated on 03-October-2017

>

References

  1. ↑ Hoette TM, Abergel RJ, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24;130(51):17584-92. doi: 10.1021/ja8074665. PMID:19053425 doi:http://dx.doi.org/10.1021/ja8074665
  2. ↑ Paragas N, Qiu A, Hollmen M, Nickolas TL, Devarajan P, Barasch J. NGAL-Siderocalin in kidney disease. Biochim Biophys Acta. 2012 Sep;1823(9):1451-8. doi: 10.1016/j.bbamcr.2012.06.014., Epub 2012 Jun 19. PMID:22728330 doi:http://dx.doi.org/10.1016/j.bbamcr.2012.06.014
  3. ↑ Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK. Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure. 2005 Jan;13(1):29-41. PMID:15642259 doi:10.1016/j.str.2004.10.009

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