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| - | ==Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2==
| + | #REDIRECT [[5vei]] This PDB entry is obsolete and replaced by 5vei |
| - | <StructureSection load='4igz' size='340' side='right' caption='[[4igz]], [[Resolution|resolution]] 1.33Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4igz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IGZ FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORBS2, ARGBP2, KIAA0777 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4igz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4igz RCSB], [http://www.ebi.ac.uk/pdbsum/4igz PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/SRBS2_HUMAN SRBS2_HUMAN]] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.<ref>PMID:9211900</ref> <ref>PMID:12475393</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Arrowsmith, C H]]
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| - | [[Category: Bakkouri, M El]]
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| - | [[Category: Bountra, C]]
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| - | [[Category: Edwards, A M]]
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| - | [[Category: Gu, J]]
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| - | [[Category: Huang, H]]
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| - | [[Category: Liu, K]]
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| - | [[Category: Liu, Y]]
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| - | [[Category: Min, J]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Sidhu, S S]]
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| - | [[Category: Tempel, W]]
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| - | [[Category: Protein binding]]
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| - | [[Category: Sgc]]
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| - | [[Category: Sh3]]
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| - | [[Category: Src homology 3 domain]]
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