1ycj
From Proteopedia
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|PDB= 1ycj |SIZE=350|CAPTION= <scene name='initialview01'>1ycj</scene>, resolution 1.95Å | |PDB= 1ycj |SIZE=350|CAPTION= <scene name='initialview01'>1ycj</scene>, resolution 1.95Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GRIK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |GENE= GRIK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ftj|1FTJ]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ycj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycj OCA], [http://www.ebi.ac.uk/pdbsum/1ycj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ycj RCSB]</span> | ||
}} | }} | ||
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[[Category: Skov, L K.]] | [[Category: Skov, L K.]] | ||
[[Category: Vestergaard, B.]] | [[Category: Vestergaard, B.]] | ||
| - | [[Category: GLU]] | ||
| - | [[Category: SO4]] | ||
[[Category: glur5 ligand-binding core]] | [[Category: glur5 ligand-binding core]] | ||
[[Category: ionotropic glutamate receptor]] | [[Category: ionotropic glutamate receptor]] | ||
[[Category: kainate receptor]] | [[Category: kainate receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:02:49 2008'' |
Revision as of 22:02, 30 March 2008
| |||||||
| , resolution 1.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | GRIK1 (Rattus norvegicus) | ||||||
| Related: | 1FTJ
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Overview
The X-ray structure of the ligand-binding core of the kainate receptor GluR5 (GluR5-S1S2) in complex with (S)-glutamate was determined to 1.95 A resolution. The overall GluR5-S1S2 structure comprises two domains and is similar to the related AMPA receptor GluR2-S1S2J. (S)-glutamate binds as in GluR2-S1S2J. Distinct features are observed for Ser741, which stabilizes a highly coordinated network of water molecules and forms an interdomain bridge. The GluR5 complex exhibits a high degree of domain closure (26 degrees) relative to apo GluR2-S1S2J. In addition, GluR5-S1S2 forms a novel dimer interface with a different arrangement of the two protomers compared to GluR2-S1S2J.
About this Structure
1YCJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate., Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS, FEBS Lett. 2005 Feb 14;579(5):1154-60. PMID:15710405
Page seeded by OCA on Mon Mar 31 01:02:49 2008
