Ribosomal protein S15

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[[Image:RPS15.png|left|200px|thumb|Crystal Structure of Ribosomal protein S15 from [[2zm6]], chain O]]
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<StructureSection load='1a32' size='350' side='right' scene='' caption='Ribosomal protein S15 (PDB code [[1a32]])'>
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{{STRUCTURE_1a32| PDB=1a32 | SIZE=400| SCENE= |right|CAPTION=Ribosomal protein S15 from [[1a32]]}}
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'''Ribosomal protein S15''' (RPS15) is one of the 21 proteins which belong to the 30S <scene name='Ribosomal_protein_S15/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]] or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. It is involved in the early steps of ribosome assembly<ref>PMID:12126618</ref>.
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'''Ribosomal protein S15''' (RPS15) is one of the 22 proteins which belong to the <scene name='Ribosomal_protein_S15/Cv/2'>small subunit</scene> of the [http://en.wikipedia.org/wiki/Bacteria bacterial] [[ribosome]]. It is involved in the early steps of ribosome assembly. The images at the left and at the right correspond to one representative RPS15, ''i.e.'' the crystal structure of Ribosomal protein S15 from ''Thermus thermophilus'' ([[2zm6]], chain O).
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{{TOC limit|limit=2}}
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== Relevance ==
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RPS15 phosphorylation mediates leucine-rich kinase 2 neurodegeneration in Parkinson's disease<ref>PMID:24725412</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein S15 ==
== 3D Structures of Ribosomal protein S15 ==
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''Update December 2011''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== S15 ===
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*Ribosomal protein S15
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[[1a32]] – RPS15 – ''Geobacillus stearothermophilus''<br />
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**[[1a32]] – RPS15 – ''Geobacillus stearothermophilus''<br />
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[[1ab3]], [[2fkx]] - TtRPS15 – ''Thermus thermophilus'' - NMR<br />
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**[[1ab3]], [[2fkx]] - TtRPS15 – ''Thermus thermophilus'' - NMR<br />
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[[1kuq]], [[1f7y]], [[1dk1]] - TtRPS15+16S RRNA fragment<br />
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**[[1kuq]], [[1f7y]], [[1dk1]] - TtRPS15+16S RRNA fragment<br />
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[[2vaz]] – EcRPS15+RPSO mRNA operator – ''Escherichia coli'' – Cryo-EM<br />
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**[[2vaz]] – EcRPS15+RPSO mRNA operator – ''Escherichia coli'' – Cryo-EM<br />
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[[3ulw]] – RPS15 – ''Campylobacter jejuni''
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**[[4iyl]] – RPS15 – ''Campylobacter jejuni''<br />
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**[[4a5u]] – EcRPS15 + RNA replicase polyprotein
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=== S15 in small ribosomal subunit ===
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*Ribosomal protein S15 in part of small ribosomal subunit
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[[2zm6]], [[1n36]], [[1j5e]], [[3oto]]- TtRPS15 in 30S ribosomal subunit+THX+16S RRNA <br />
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[[2vqe]], [[2vqf]], [[2uuc]], [[2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+RNA fragment<br />
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[[3i8g]], [[3i8h]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA+tRNA-Phe<br />
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[[3kc4]] – EcRPS15 in 30S ribosomal subunit <br />
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[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]], [[3ofo]], [[3ofp]], [[3or9]], [[3ora]], [[3kc4]] - EcRPS15 in 30S ribosomal subunit+16S RRNA<br />
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[[1i94]], [[1fka]], [[3uxs]], [[3uxt]] - TtRPS15 in 30S ribosomal subunit+16S RRNA<br />
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[[1p87]], [[1p6g]] - EcRPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM<br />
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[[3bbn]] - RPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach<br />
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[[2zkq]] – RPS15 in 40S ribosomal subunit+18S RRNA - dog<br />
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=== S15 in small + large ribosomal subunit ===
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[[1ml5]], [[1eg0]] - EcRPS15 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM<br />
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[[3j0l]], [[3j0o]], [[3j0p]], [[3j0q]] - RPS15 in 30S ribosomal subunit+50S ribosomal subunit+ RRNA fragments +mRNA fragment+ tRNA – rabbit - Cryo EM
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=== S15 in small ribosomal subunit+ chain release factor ===
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[[3mr8]], [[3ms0]] – TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA <br />
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[[3d5a]], [[3d5c]], [[3f1e]], [[3f1g]] - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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[[3zvo]] – TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
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[[2b64]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
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[[2b9m]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
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[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
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[[3f1e]], [[3f1g]] - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
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[[3uoq]] - EcRPS15 + 16S RRNA + mRNA + peptide chain release factor<br />
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=== S15 in small ribosomal subunit+tRNA+mRNA ===
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[[2hgi]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
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[[2hgp]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[3t1h]], [[3t1y]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Lys +mRNA<br />
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[[3tvf]], [[3tvg]], [[3uyd]], [[3uyf]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA<br />
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[[3uz6]], [[3uz7]], [[3uzg]], [[3uzi]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA<br />
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[[2i2p]], [[2i2u]] - EcRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
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[[2hgr]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
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[[1yl4]] – TtRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
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[[1pns]] - EcRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
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[[3j0u]], [[3j0v]], [[3j0x]], [[3j0z]], [[3j10]] – EcRPS15 in 30S ribosomal subunit+ A-site tRNA + P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
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[[3j13]] – EcRPS15 in 30S ribosomal subunit+ P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
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[[1xnq]], [[1xnr]] - TtRPS15 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA<br />
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=== S15 in small ribosomal subunit+A-site tRNA ===
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[[2uxd]], [[2uxc]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
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[[1n32]], [[1n33]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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[[1n34]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
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[[1xmo]], [[1xmq]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
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[[2uxb]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA<br />
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=== S15 in small ribosomal subunit+P-site tRNA ===
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[[3i8g]] - TtRPS15 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
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[[3i8h]], [[3i9b]], [[3i9d]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
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[[1ibk]] - TtRPS15 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
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[[2wwl]] - EcRPS15 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - ''Escherichia coli''<br />
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[[3i1q]] - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA<br />
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[[3i1s]], [[3i1z]], [[3i21]] - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA<br />
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=== S15 in small ribosomal subunit+A-site tRNA+P-site tRNA ===
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[[1ibl]], [[1ibm]] - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA<br />
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=== S15 in small ribosomal subunit+P-site tRNA+E-site tRNA ===
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[[2ow8]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
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**[[3iy8]] - EcRPS15+EcRPS5+EcRPS6+EcRPS9+ EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA<br />
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[[2b9o]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
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**[[1g1x]] - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment<br />
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[[2qnh]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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**[[1qd7]] – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment<br />
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}}
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=== S15 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA ===
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== References ==
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<references/>
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[[2gy9]], [[2gyb]] - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
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[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
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[[3e1a]], [[3e1c]] - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
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=== S15 in small ribosomal subunit + antibiotics ===
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[[1i95]], [[1i97]], [[2hhh]], [[2f4v]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]]- TtRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[1hnw]], [[1hnx]], [[1hnz]], [[1fjg]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic<br />
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[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]], [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy]], [[2qp0]], [[2z4k]], [[2z4m]], [[3oaq]], [[3oar]], [[3ofa]], [[3ofb]], [[3ofo]], [[3ofp]], [[3ofx]], [[3ofy]] - EcRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic<br />
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[[2j00]], [[2j02]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
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[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin<br />
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[[3knj]], [[3knh]] - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin<br />
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[[3knl]], [[3knn]] - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin<br />
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[[3uz3]], [[3uz4]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA + paromomycin<br />
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[[3uzl]], [[3uzm]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA + paromomycin
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=== S15 in small ribosomal subunit + ribosome recycling factor ===
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[[2qbd]], [[2qbf]] – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
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[[3r8n]], [[3r8o]] – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
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[[2qbh]], [[2qbj]] - EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
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[[2v46]], [[2v48]] - TtRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet<br />
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=== S15 in small ribosomal subunit + elongation factor ===
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[[2wri]], [[2wrk]] - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
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[[2wrn]], [[2wrq]] - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
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[[3fic]] - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
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[[4abr]] - TtRPS15 in 30S ribosomal subunit+THX + E/P-site tRNA fMet +mRNA codon+16S RRNA+elongation factor TU<br />
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[[3izv]] – EcRPS15 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
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[[3j18]] - EcRPS15 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+ mRNA + SSRA-binding protein + formyl-Met specific initiator tRNA + elongation factor G – Cryo-EM<br />
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[[3izw]] – EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
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[[2y0u]], [[2y0w]], [[2y0y]], [[2y10]], [[2y12]], [[2y14]], [[2y16]], [[2y18]] - TtRPS15 in 30S subunit+THX+A-site tRNA+E-site tRMA+mRNA codon+16S RRNA+elongation factor TU<br />
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[[3fih]] - EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
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[[3huw]], [[3huy]] - TtRPS15 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
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[[1s1h]] - yRPS15 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
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=== S15 in small ribosomal subunit + translation initiation factor ===
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[[1i96]] - TtRPS15 in 30S ribosomal subunit+THX+IF3+16S RRNA<br />
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[[1hr0]] - TtRPS15 in 30S ribosomal subunit+THX+IF+16S RRNA<br />
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=== S15 in small ribosomal subunit + various proteins ===
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[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - TtRPS15 in 30S ribosomal subunit+toxin RelE+16S RRNA<br />
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[[4dh9]], [[4dhb]] - TtRPS15 in 30S ribosomal subunit +16S RRNA+mRNA+P-site tRNA fMet +THX + YAEJ<br />
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[[1voq]], [[1vos]], [[1vov]], [[1vox]], [[1voz]] - EcRPS15 in 30S ribosomal subunit+protein Y+16S RRNA<br />
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[[2xfz]], [[2xg1]] - TtRPS15 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA<br />
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[[3jyv]] - RPS15+RPS0+RPS2+RPS3+RPS5+RPS9+RPS11+RPS13+RPS14+RPS16+RPS18+RPS20+RPS22+RPS23+RPS29+18S RRNA+RACK1+S19E+tRNA – Cryo-EM - ''Thermomyces lanuginosus''<br />
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[[2ykr]] – EcRPS15 + 16S RRNA + GMPPNP + GTPase RSGA<br />
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[[4adv]] - EcRPS15 + 16S RRNA + methyltransferase – Cryo EM<br />
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[[4a2i]] – EcRPS15 + 16S RRNA + GTPase RSGA – Cryo EM
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===S15 in small 40S ribosomal subunit + various proteins===
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[[3iz6]] - RPS15 in 40S ribosomal subunit +RACK1+18S RRNA – wheat – Cryo-EM<br />
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[[3izb]] - yRPS15 in 40S ribosomal subunit+ RACK1 – yeast - Cryo-EM<br />
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[[3u5c]], [[3u5g]] - yRPS15 in 40S ribosomal subunit+ RACK1 + suppressor protein SMT1<br />
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[[3o2z]], [[3o30]] - yRPS15 in 40S ribosomal subunit +RACK1
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=== S15 in part of small ribosomal subunit ===
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[[3iy8]] - EcRPS15+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA<br />
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[[1g1x]] - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment<br />
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[[1qd7]] – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein S15 (PDB code 1a32)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein S15

Updated on 10-October-2017

References

  1. ↑ Serganov A, Ennifar E, Portier C, Ehresmann B, Ehresmann C. Do mRNA and rRNA binding sites of E.coli ribosomal protein S15 share common structural determinants? J Mol Biol. 2002 Jul 26;320(5):963-78. PMID:12126618 doi:http://dx.doi.org/10.1016/S0022283602005533
  2. ↑ Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL. Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Cell. 2014 Apr 10;157(2):472-85. doi: 10.1016/j.cell.2014.01.064. PMID:24725412 doi:http://dx.doi.org/10.1016/j.cell.2014.01.064

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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