Topoisomerase binding protein
From Proteopedia
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| - | <StructureSection load='3ueo' size='450' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (PDB entry [[3ueo]])' scene='56/564070/Cv/4'> | + | <StructureSection load='3ueo' size='450' side='right' caption='Structure of human topoisomerase binding protein 1 BRCT 4-5 domain complex with phospho-peptide (magenta) (PDB entry [[3ueo]])' scene='56/564070/Cv/4'> |
== Function == | == Function == | ||
'''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | '''Topoisomerase binding protein''' (TopBP1) interacts with the C-terminal of topoisomerase II beta. TopBP1 is required for DNA replication. It binds double-stranded DNA breaks and nicks and plays a role in rescuing stalled DNA replication forks<ref>PMID:9461304</ref>. | ||
Revision as of 21:19, 10 October 2017
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