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Tumor necrosis factor

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<StructureSection load='2az5' size='400' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
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<StructureSection load='' size='400' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'>
== Function ==
== Function ==
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).

Revision as of 04:01, 16 October 2017

Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5)

Drag the structure with the mouse to rotate

3D Structures of tumor necrosis factor

Updated on 16-October-2017

References

  1. ↑ Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep;11(9):372-7. PMID:11514191
  2. ↑ Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3. PMID:19343034 doi:http://dx.doi.org/10.1038/nrc2628

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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