Plasmid segregation protein ParM

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Revision as of 22:53, 21 October 2017

spinqualitylabelsall models plasmid segregation protein ParM complex with AMPPNP and Mg+2 ion (green) (PDB code 4a61) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Plasmid segregation protein (ParM) is required for plasmid partition and accurate segregation of low-copy-number plasmid R1[1]. Structural highlights ParM polymerizes into double helical protofilaments with repeats similar to F-actin. . . Water molecules shown as red spheres.

3D structures of plasmid segregation protein ParM

Updated on 21-October-2017

1mwk – ParM – Escherichias coli
1mwm – ParM + ADP
2zgy – ParM + GDP
2zgz – ParM + GMPPNP
4a61 – ParM + AMPPNP
5aey – ParM + AMPPNP - CryoEM
4a62 – ParM + ParR C terminus
2qu4, 2ghc, 3iku, 3iky, 4a6j, 5ai7 – ParM – CryoEM
2zhc – ParM + ADP - CryoEM

References

1. ↑ Salje J, Gayathri P, Lowe J. The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments. Nat Rev Microbiol. 2010 Oct;8(10):683-92. doi: 10.1038/nrmicro2425. PMID:20844556 doi:http://dx.doi.org/10.1038/nrmicro2425