This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5xo2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5xo2" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5xo2 is ON HOLD until Paper Publication
+
==Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide II==
-
 
+
<StructureSection load='5xo2' size='340' side='right' caption='[[5xo2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5xo2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XO2 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8B9:N-[(2S,3R,4S,6S)-6-(hydroxymethyl)-2,4-bis(oxidanyl)oxan-3-yl]ethanamide'>8B9</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xo2 OCA], [http://pdbe.org/5xo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/5xo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xo2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN]] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref> [[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Anada, M]]
 +
[[Category: Arase, H]]
 +
[[Category: Furukawa, A]]
 +
[[Category: Hashimoto, S]]
 +
[[Category: Hatori, N]]
 +
[[Category: Ishizuka, M]]
 +
[[Category: Kakita, K]]
 +
[[Category: Kuroki, K]]
 +
[[Category: Maeda, N]]
 +
[[Category: Maenaka, K]]
 +
[[Category: Matsunaga, S]]
 +
[[Category: Nambu, H]]
 +
[[Category: Nomura, T]]
 +
[[Category: Ohsaka, F]]
 +
[[Category: Ose, T]]
 +
[[Category: Saitoh, T]]
 +
[[Category: Sakamoto, J]]
 +
[[Category: Yamada, T]]
 +
[[Category: Glycopeptide]]
 +
[[Category: Immune receptor]]
 +
[[Category: Immune system]]
 +
[[Category: Membrane protein]]
 +
[[Category: Viral entry inhibitor]]

Revision as of 07:19, 25 October 2017

Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide II

5xo2, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5xo2"
Personal tools