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1zii
From Proteopedia
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|PDB= 1zii |SIZE=350|CAPTION= <scene name='initialview01'>1zii</scene>, resolution 1.8Å | |PDB= 1zii |SIZE=350|CAPTION= <scene name='initialview01'>1zii</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zii OCA], [http://www.ebi.ac.uk/pdbsum/1zii PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zii RCSB]</span> | ||
}} | }} | ||
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[[Category: Junior, L Gonzalez.]] | [[Category: Junior, L Gonzalez.]] | ||
[[Category: Richardson, D.]] | [[Category: Richardson, D.]] | ||
| - | [[Category: ACE]] | ||
[[Category: activator]] | [[Category: activator]] | ||
[[Category: amino-acid biosynthesis]] | [[Category: amino-acid biosynthesis]] | ||
| Line 35: | Line 37: | ||
[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:37:08 2008'' |
Revision as of 22:37, 30 March 2008
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| , resolution 1.8Å | |||||||
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| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
GCN4-LEUCINE ZIPPER CORE MUTANT ASN16ABA IN THE DIMERIC STATE
Overview
Each protein sequence generally adopts a single native fold, but the sequence features that confer structural uniqueness are not well understood. To define the basis for structural heterogeneity, we determined the high resolution X-ray crystal structures of a single GCN4 leucine-zipper mutant (Asn 16 to aminobutyric acid) in both dimeric and trimeric coiled-coil conformations. The mutant sequence is accommodated in two distinct structures by forming similarly-shaped packing surfaces with different sets of atoms. The trimer structure, in comparison to a previously-characterized trimeric mutant with substitutions in eight core residues, shows that the twist of individual helices and the helix-helix crossing angles can vary significantly to produce the most favoured packing arrangement.
About this Structure
1ZII is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism., Gonzalez L Jr, Brown RA, Richardson D, Alber T, Nat Struct Biol. 1996 Dec;3(12):1002-9. PMID:8946853
Page seeded by OCA on Mon Mar 31 01:37:08 2008
