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3n55

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[[Image:3n55.png|left|200px]]
 
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{{STRUCTURE_3n55| PDB=3n55 | SCENE= }}
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==SO1698 protein, an aspartic peptidase from Shewanella oneidensis.==
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<StructureSection load='3n55' size='340' side='right' caption='[[3n55]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3n55]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700550 Atcc 700550]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ai4 2ai4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N55 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SO_1698 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70863 ATCC 700550])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n55 OCA], [http://pdbe.org/3n55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n55 RCSB], [http://www.ebi.ac.uk/pdbsum/3n55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n55 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n5/3n55_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n55 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of SO1698 protein from Shewanella oneidensis was determined by a SAD method and refined to 1.57 A. The structure is a beta sandwich that unexpectedly consists of two polypeptides; the N-terminal fragment includes residues 1-116, and the C-terminal one includes residues 117-125. Electron density also displayed the Lys-98 side chain covalently linked to Asp-116. The putative active site residues involved in self-cleavage were identified; point mutants were produced and characterized structurally and in a biochemical assay. Numerical simulations utilizing molecular dynamics and hybrid quantum/classical calculations suggest a mechanism involving activation of a water molecule coordinated by a catalytic aspartic acid.
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===SO1698 protein, an aspartic peptidase from Shewanella oneidensis.===
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Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase.,Osipiuk J, Mulligan R, Bargassa M, Hamilton JE, Cunningham MA, Joachimiak A J Biol Chem. 2012 Jun 1;287(23):19452-61. Epub 2012 Apr 5. PMID:22493430<ref>PMID:22493430</ref>
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{{ABSTRACT_PUBMED_22493430}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3n55" style="background-color:#fffaf0;"></div>
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[[3n55]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ai4 2ai4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N55 OCA].
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== References ==
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[[Category: Collart, F.]]
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<references/>
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[[Category: Joachimiak, A.]]
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__TOC__
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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</StructureSection>
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[[Category: Mulligan, R.]]
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[[Category: Atcc 700550]]
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[[Category: Osipiuk, J.]]
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[[Category: Collart, F]]
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[[Category: Joachimiak, A]]
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[[Category: Structural genomic]]
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[[Category: Mulligan, R]]
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[[Category: Osipiuk, J]]
[[Category: Aspartic peptidase]]
[[Category: Aspartic peptidase]]
[[Category: Autocatalysis]]
[[Category: Autocatalysis]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Current revision

SO1698 protein, an aspartic peptidase from Shewanella oneidensis.

3n55, resolution 1.57Å

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