2ad9
From Proteopedia
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|PDB= 2ad9 |SIZE=350|CAPTION= <scene name='initialview01'>2ad9</scene> | |PDB= 2ad9 |SIZE=350|CAPTION= <scene name='initialview01'>2ad9</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2adb|2ADB]], [[2adc|2ADC]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ad9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad9 OCA], [http://www.ebi.ac.uk/pdbsum/2ad9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ad9 RCSB]</span> | ||
}} | }} | ||
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[[Category: rrm]] | [[Category: rrm]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:01 2008'' |
Revision as of 22:51, 30 March 2008
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| Ligands: | , | ||||||
| Gene: | PTB-1 (Homo sapiens) | ||||||
| Related: | 2ADB, 2ADC
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
Overview
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
About this Structure
2AD9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478
Page seeded by OCA on Mon Mar 31 01:51:01 2008
Categories: Homo sapiens | Single protein | Allain, F H.T. | Auweter, S D. | Black, D L. | Erat, M. | Hargous, Y. | Henning, A. | Oberstrass, F C. | Pitsch, S. | Reymond, L. | Wenter, P. | Protein-rna complex | Rbd | Rrm
