2as0

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|GENE= PH1915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
|GENE= PH1915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02475 Met_10], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1092 COG1092], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00359 PUA]</span>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02475 Met_10], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1092 COG1092], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00359 PUA]</span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2as0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2as0 OCA], [http://www.ebi.ac.uk/pdbsum/2as0 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2as0 RCSB]</span>
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2as0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2as0 OCA], [http://www.ebi.ac.uk/pdbsum/2as0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2as0 RCSB]</span>
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[[Category: structural genomic]]
[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:21:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:56:31 2008''

Revision as of 22:56, 30 March 2008

Image:2as0.gif


PDB ID 2as0

Drag the structure with the mouse to rotate
, resolution 1.80Å
Ligands:
Gene: PH1915 (Pyrococcus horikoshii)
Domains: Met_10, COG1092, PUA
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase


Overview

The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.

About this Structure

2AS0 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:16260766

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