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5uvx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==BRD4 Bromodomain 2 with A-1359643== | |
| - | + | <StructureSection load='5uvx' size='340' side='right' caption='[[5uvx]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5uvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UVX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NM:N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]methanesulfonamide'>8NM</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uvs|5uvs]], [[5uvu|5uvu]], [[5uvt|5uvt]], [[5uvv|5uvv]], [[5uvz|5uvz]], [[5uvy|5uvy]], [[5uvw|5uvw]]</td></tr> |
| - | [[Category: Park, C | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvx OCA], [http://pdbe.org/5uvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uvx RCSB], [http://www.ebi.ac.uk/pdbsum/5uvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Park, C H]] | ||
| + | [[Category: Helix bundle]] | ||
| + | [[Category: Signaling protein-inhibitor complex]] | ||
Revision as of 09:02, 16 November 2017
BRD4 Bromodomain 2 with A-1359643
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