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Apoptotic protease-activating factor

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<StructureSection load='5juy' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry [[5juy]]) ' scene=''>
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<StructureSection load='' size='340' side='right' caption='Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry [[5juy]]) ' scene=''>

Revision as of 21:59, 20 November 2017

Human apoptosis protease-activating factor-1 (grey) complex with cytochrome c (red) and caspase 9 (pale blue) forming the apoptosome (PDB entry 5juy)

Drag the structure with the mouse to rotate

3D structures of apoptosis protease-activating factor-1

Updated on 20-November-2017

2ygs, 1cy5, 2p1h – hAPAF-1 CARD domain – human
1c15, 1cww – hAPAF-1 CARD domain – NMR
1z6t – hAPAF-1 + ADP
3ygs – hAPAF-1 CARD domain + procaspase 9
4rhw, 5wvc – hAPAF-1 CARD domain + caspase 9
3j2t, 3jbt – hAPAF-1 + cytochrome c
5juy, 5wve – hAPAF-1 + caspase 9 + cytochrome c

References

  1. ↑ Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969 doi:10.1038/nature03465
  2. ↑ Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, Furukawa Y. Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res. 2005 Jun;3(6):325-34. PMID:15972851 doi:http://dx.doi.org/10.1158/1541-7786.MCR-04-0105
  3. ↑ Shalaeva DN, Dibrova DV, Galperin MY, Mulkidjanian AY. Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. Biol Direct. 2015 May 27;10:29. doi: 10.1186/s13062-015-0059-4. PMID:26014357 doi:http://dx.doi.org/10.1186/s13062-015-0059-4

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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